![1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea structure, CAS 896466-04-9](/structures/60000/58971_1_896466_04_9.png)
CAS Number896466-04-9
SynonymsAT9283; 1-Cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}harnstoff; 1-Cyclopropyl-3-{3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea; 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea; S1134_Selleck; cc-56; AT-9283,AT 9283; AT-9283
Molecular FormulaC19H23N7O2
Molecular Weight381.43
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 896466-04-9 |
| Catalog No. | 2A-9058971 |
| Chinese Name | 1-环丙基-3-(3-(5-(吗啉甲基)-1H-苯并[d]咪唑-2-基)-1H-吡唑-4-基)脲 |
| Synonyms | AT9283; 1-Cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}harnstoff; 1-Cyclopropyl-3-{3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea; 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea; S1134_Selleck; cc-56; AT-9283,AT 9283; AT-9283 |
| Molecular Formula | C19H23N7O2 |
| Molecular Weight | 381.43 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | AT9283 is a multi-target kinase inhibitor that effectively inhibits Aurora kinase A/B, JAK2/3 (IC50=1.2 nM, 1.1 nM). |
| HTC | 2934999090 |
| MDL Number | MFCD12031513 |
| SMILES | [nH]1nc(c(c1)NC(=O)NC5CC5)c2[nH]c3c(n2)ccc(c3)CN4CCOCC4 |
| InChI | 1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27) |
| InChI Key | LOLPPWBBNUVNQZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/58971_1_896466_04_9.pdf |
| Use of | Properties Name 1-cyclopropyl-3-[(3Z)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazol-4-yl]urea Synonym More Synonyms AT9283 Biological Activity Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Cancer JAK2:1.2 nM (IC50) JAK3:1.1 nM (IC50) Aurora A:3 nM (IC50) Aurora B:3 nM (IC50) Abl (T315I):4 nM (IC50) References [1]. Howard S, et al. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Journal of Medicinal Chemistry (2009), 52(2), 379-388. [2]. Qi W, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012 Jun 15;130(12):2997-3005. [3]. Santo L, et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res. 2011 May 15;17(10):3259-71 Chemical & Physical Properties Molecular Formula C19H23N7O2 Exact Mass 381.191315 PSA 110.96000 Index of Refraction 1.715 Storage condition -20℃ Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page CAS#:896466-73-2 CAS#:896466-74-3 Cyclopropanamine CAS#:765-30-0 CAS#:896466-04-9 3-[5-(morpholin... CAS#:825619-30-5 N,N-Carbonyldii... CAS#:530-62-1 Cyclopropanamine CAS#:765-30-0 CAS#:896466-04-9 Literature: Howard, Steven; Berdini, Valerio; Boulstridge, John A.; Carr, Maria G.; Cross, David M.; Curry, Jayne; Devine, Lindsay A.; Early, Theresa R.; Fazal, Lynsey; Gill, Adrian L.; Heathcote, Michelle; Maman, Sarita; Matthews, Julia E.; McMenamin, Rachel L.; Navarro, Eva F.; O'Brien, Michael A.; O'Reilly, Marc; Rees, David C.; Reule, Matthias; Tisi, Dominic; Williams, Glyn; Vinkovic, Mladen; Wyatt, Paul G. Journal of Medicinal Chemistry, 2009 , vol. 52, # 2 p. 379 - 388 CAS#:896466-73-2 Cyclopropanamine CAS#:765-30-0 CAS#:896466-04-9 Precursor & DownStream Precursor 3 CAS#:765-30-0 Cyclopropanamine CAS#:825619-30-5 3-[5-(morpholin... CAS#:530-62-1 N,N-Carbonyldii... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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