CAS Number611-36-9
Synonyms4-Quinolinol; Chinolin-4-ol; p-hydroxyquinoline; 4-quinolone; 4(1H)-QUINOLINONE; Chinolin-4(1H)-on; Quinolin-4(1H)-one; quinolin-4-one; 1,4-Dihydroquinoline-4-one; HYDROXYQUINOLINE,4; 4-hydroxyquinoline acid; KYNURINE; 4-Hydroxyquinoline; 4-oxo-1,4-dihydroquinoline; 4-hydroxy-quinolin; EINECS 210-268-2; quinolin-4-ol; quinoline-4-ol; MFCD00006777
Molecular FormulaC9H7NO
Molecular Weight145.16
Purity98%
Density1.3±0.1 g/cm3
Boiling Point313.0±15.0 °C at 760 mmHg
Melting Point200-202 °C (lit.)
AppearanceLight yellow and off-white crystal powder
EINECS210-268-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 611-36-9 |
| Catalog No. | 2A-9005897 |
| Chinese Name | 4-羟基喹啉 |
| Synonyms | 4-Quinolinol; Chinolin-4-ol; p-hydroxyquinoline; 4-quinolone; 4(1H)-QUINOLINONE; Chinolin-4(1H)-on; Quinolin-4(1H)-one; quinolin-4-one; 1,4-Dihydroquinoline-4-one; HYDROXYQUINOLINE,4; 4-hydroxyquinoline acid; KYNURINE; 4-Hydroxyquinoline; 4-oxo-1,4-dihydroquinoline; 4-hydroxy-quinolin; EINECS 210-268-2; quinolin-4-ol; quinoline-4-ol; MFCD00006777 |
| Molecular Formula | C9H7NO |
| Molecular Weight | 145.16 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 313.0±15.0 °C at 760 mmHg |
| Melting Point | 200-202 °C (lit.) |
| Appearance | Light yellow and off-white crystal powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Storage: Seal the container and store it in a seal |
| Application | 4-Quinolone (Kynurine) is a quinoline derivative. The Kynurine pathway regulates tryptophan metabolism and participates in neuroprotection. Kynurine promotes tumor cell survival and movement by suppre |
| EINECS | 210-268-2 |
| HTC | 2933499090 |
| PubChem ID | 24895711 |
| MDL Number | MFCD00006777 |
| SMILES | Oc1ccnc2ccccc12 |
| InChI | 1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11) |
| InChI Key | PMZDQRJGMBOQBF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2900 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S37/39 |
| MSDS | msds/5897_1_611_36_9.pdf |
| Bioactivity | 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2]. Related Catalog Research Areas >> Cancer Research Areas >> Neurological Disease In Vitro 4-Quinolone (Kynurine) promotes tumor cell survival and motility by suppressing antitumor immune responses through AhR in an autocrine/paracrine fashion. This system is particularly active in human brain tumors where the activation of AhR enhances the expression of TDO producing more kynurine and kynurinic acid. In the healthy human brain, very low levels of TDO exist, whereas, in human brain tumors, the TDO protein levels increase with malignancy[3]. References [1]. Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8. [2]. Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174. [3]. Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 313.0±15.0 °C at 760 mmHg Melting Point 200-202 °C(lit.) Molecular Formula C9H7NO Molecular Weight 145.158 Flash Point 143.1±20.4 °C Exact Mass 145.052765 PSA 33.12000 LogP 2.45 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.691 |
| Use of | 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2]. Properties Articles21 Name quinolin-4-ol Synonym More Synonyms 4-quinolone Biological Activity Description 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2]. Related Catalog Research Areas >> Cancer Research Areas >> Neurological Disease In Vitro 4-Quinolone (Kynurine) promotes tumor cell survival and motility by suppressing antitumor immune responses through AhR in an autocrine/paracrine fashion. This system is particularly active in human brain tumors where the activation of AhR enhances the expression of TDO producing more kynurine and kynurinic acid. In the healthy human brain, very low levels of TDO exist, whereas, in human brain tumors, the TDO protein levels increase with malignancy[3]. References [1]. Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8. [2]. Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174. [3]. Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203. Chemical & Physical Properties Molecular Formula C9H7NO Exact Mass 145.052765 PSA 33.12000 Index of Refraction 1.691 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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