CAS Number156-38-7
Synonyms4-Hydroxyphenyl acetic acid; 2-(4-Hydroxyphenyl)acetic acid; 4-hydroxyphenylacetic acid; (p-hydroxyphenyl)-Acetic acid; (4-Hydroxy-phenyl)-acetic acid; 4-Hydroxy-Benzeneacetic acid; (4-Hydroxyphenyl)acetic acid; MFCD00004347; EINECS 205-851-3; PHPA
Molecular FormulaHOC6H4CH2CO2H
Molecular Weight152.15
Purity98%
Density1.3±0.1 g/cm3
Boiling Point346.6±17.0 °C at 760 mmHg
Melting Point148-151 °C (lit.)
AppearanceWhite or light yellow crystalline powder
EINECS205-851-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 156-38-7 |
| Catalog No. | 2A-9005892 |
| Chinese Name | 对羟基苯乙酸 |
| Synonyms | 4-Hydroxyphenyl acetic acid; 2-(4-Hydroxyphenyl)acetic acid; 4-hydroxyphenylacetic acid; (p-hydroxyphenyl)-Acetic acid; (4-Hydroxy-phenyl)-acetic acid; 4-Hydroxy-Benzeneacetic acid; (4-Hydroxyphenyl)acetic acid; MFCD00004347; EINECS 205-851-3; PHPA |
| Molecular Formula | HOC6H4CH2CO2H |
| Molecular Weight | 152.15 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 346.6±17.0 °C at 760 mmHg |
| Melting Point | 148-151 °C (lit.) |
| Appearance | White or light yellow crystalline powder |
| Storage Condition | Store in an airtight container and in a cool, dry |
| Application | 4-Hydroxyphenylacetic acid is a major microbiota-derived polyphenol metabolite with antioxidant effects. 4-hydroxyphenylacetic acid induces Nrf2 expression [1]. |
| EINECS | 205-851-3 |
| HTC | 2918290000 |
| PubChem ID | 24895664 |
| MDL Number | MFCD00004347 |
| SMILES | OC(=O)Cc1ccc(O)cc1 |
| InChI | 1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11) |
| InChI Key | XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1448766 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | R36/37/38 |
| Safety Description | S24/25 |
| MSDS | msds/5892_1_156_38_7.pdf |
| Bioactivity | 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1]. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Phenols Research Areas >> Metabolic Disease Target Nrf2[1] In Vivo 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1]. References [1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 346.6±17.0 °C at 760 mmHg Melting Point 148-151 °C(lit.) Molecular Formula C8H8O3 Molecular Weight 152.147 Flash Point 177.6±17.4 °C Exact Mass 152.047348 PSA 57.53000 LogP 0.77 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.596 InChIKey XQXPVVBIMDBYFF-UHFFFAOYSA-N SMILES O=C(O)Cc1ccc(O)cc1 |
| Use of | 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1]. Properties Articles80 Name 4-hydroxyphenylacetic acid Synonym More Synonyms 4-Hydroxyphenylacetic acid Biological Activity Description 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1]. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Phenols Research Areas >> Metabolic Disease References [1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. Chemical & Physical Properties Molecular Formula C8H8O3 Exact Mass 152.047348 PSA 57.53000 Index of Refraction 1.596 InChIKey XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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