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4'-Hydroxychalcone structure, CAS 2657-25-2

4'-Hydroxychalcone

CAS Number2657-25-2

SynonymsMFCD00016484; 4'-HYDROXYCHALCONE; HYDROXYCHALCONE,4'; 4′-Hydroxychalcone; 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one

Molecular FormulaC15H12O2

Molecular Weight224.26

Purity97%

Density1.191 g/cm3

Boiling Point419.6ºC at 760 mmHg

Melting Point174-178 °C

Flash Point

AppearanceYellow-cream powder

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Cat. No.: 2A-9005883 Purity: 97%
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Quality Control of [ 2657-25-2 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2657-25-2
Catalog No.2A-9005883
Chinese Name4'-羟基查耳酮
SynonymsMFCD00016484; 4'-HYDROXYCHALCONE; HYDROXYCHALCONE,4'; 4′-Hydroxychalcone; 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one
Molecular FormulaC15H12O2
Molecular Weight224.26
Purity97
Density1.191 g/cm3
Boiling Point419.6ºC at 760 mmHg
Melting Point174-178 °C
AppearanceYellow-cream powder
Storage ConditionSealed in a cool, dry environment
Application4'-Hydroxychalcone is a chalcone isolated from licorice root and has liver-protective effects. 4'-Hydroxychalcone can inhibit TNFα-induced NF-κB activity by inhibiting the proteasome. 4'-Hydroxychalco
MDL NumberMFCD00016484
SMILESO=C(C=Cc1ccccc1)c1ccc(O)cc1
InChIInChI=1S/C15H12O2/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11,16H/b11-6+
InChI KeyUAHGNXFYLAJDIN-IZZDOVSWSA-N
MSDSmsds/5883_1_2657_25_2.pdf
Bioactivity4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. [2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2). [3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31. Chemical & Physical Properties Density 1.191 g/cm3 Boiling Point 419.6ºC at 760 mmHg Melting Point 174-178 °C Molecular Formula C15H12O2 Molecular Weight 224.25500 Flash Point 179.1ºC Exact Mass 224.08400 PSA 37.30000 LogP 3.28830 Vapour Pressure 1.23E-07mmHg at 25°C Index of Refraction 1.653 InChIKey UAHGNXFYLAJDIN-IZZDOVSWSA-N SMILES O=C(C=Cc1ccccc1)c1ccc(O)cc1
Use of4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3]. Properties Name 4'-hydroxychalcone Synonym More Synonyms 2-Benzal-4-hydroxyacetophenone Biological Activity Description 4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. [2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2). [3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31. Chemical & Physical Properties Molecular Formula C15H12O2 Exact Mass 224.08400 PSA 37.30000 LogP 3.28830 Index of Refraction 1.653 InChIKey UAHGNXFYLAJDIN-IZZDOVSWSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified 4'-Hydroxychalcone Modification Number: 5
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