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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

Name: N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
Brand: 2A Biotech
SKU: 2A-9058742

CAS Number881202-45-5

Synonyms1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine; Serdemetan; N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine; JNJ 26854165

Molecular FormulaC21H20N4

Molecular Weight328.41

Purity≥98 (HPLC)%

Density1.3±0.1 g/cm3

Boiling Point615.1±50.0 °C at 760 mmHg

Appearancepowder

MSDSChinese English

Cat. No.: 2A-9058742 Purity: ≥98 (HPLC)%

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Quality Control of [ 881202-45-5 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	881202-45-5
Catalog No.	2A-9058742
Chinese Name	谢尔德梅坦(JNJ-26854165)
Synonyms	1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine; Serdemetan; N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine; JNJ 26854165
Molecular Formula	C21H20N4
Molecular Weight	328.41
Purity	≥98 (HPLC)
Density	1.3±0.1 g/cm3
Boiling Point	615.1±50.0 °C at 760 mmHg
Appearance	powder
Storage Condition	-20℃
Application	Serdemetan (JNJ-26854165) is an HDM2 ubiquitin ligase antagonist that can induce early apoptosis in p53 wild-type cells.
HTC	2933990090
MDL Number	MFCD16620518
SMILES	[nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2
InChI Key	CEGSUKYESLWKJP-UHFFFAOYSA-N
NACRES Code	NA.77
UNSPSC	12352200
MSDS	msds/58742_1_881202_45_5.pdf
Use of	Properties Name N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine Synonym More Synonyms Serdemetan Biological Activity Related Catalog Research Areas >> Cancer References [1]. T. Stühmer et al. A first-in-class HDM2-inhibitor (JNJ-26854165) in phase I development shows potent activity against multiple myeloma (MM) cells in vitro and ex vivo Journal of Clinical Oncology, 2008 ASCO Annual Meeting Proceedings (Post-Meeting Edition ).Vol 26, No 15S (May 20 Supplement), 2008: 14694 [2]. Chargari C, Leteur C, Angevin E, Bashir T, Schoentjes B, Arts J, Janicot M, Bourhis J, Deutsch E.Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts.Cancer Lett. 2011 Dec 22;312(2):209-18. [3]. Smith MA, Gorlick R, Kolb EA, Lock R, Carol H, Maris JM, Keir ST, Morton CL, Reynolds CP, Kang MH, Arts J, Bashir T, Janicot M, Kurmasheva RT, Houghton PJ.Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program.Pediatr Blood Cancer. 2012 Aug;59(2):329-32. [4]. Tabernero J, Dirix L, Sch?ffski P, Cervantes A, Lopez-Martin JA, Capdevila J, van Beijsterveldt L, Platero S, Hall B, Yuan Z, Knoblauch R, Zhuang SH.A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors.Clin Cancer Res. 2011 Oct 1;17(19):6313-21. Epub 2011 Aug 10. [5]. Kojima K, Burks JK, Arts J, Andreeff M.The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.Mol Cancer Ther. 2010 Sep;9(9):2545-57. Epub 2010 Aug 24. Chemical & Physical Properties Molecular Formula C21H20N4 Exact Mass 328.168793 PSA 52.74000 Appearance of Characters brown solid Index of Refraction 1.747 InChIKey CEGSUKYESLWKJP-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933990090
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

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