![4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile structure, CAS 871307-18-5](/structures/60000/58641_1_871307_18_5.png)
CAS Number871307-18-5
Synonyms4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile; 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
Molecular FormulaC21H14ClFN6
Molecular Weight404.83
Purity≥95 (HPLC)%
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 871307-18-5 |
| Catalog No. | 2A-9058641 |
| Chinese Name | 4-[(3-氯-4-氟苯基)氨基]-6-[(3-吡啶甲基)氨基]-1,7-萘啶-3-甲腈 |
| Synonyms | 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile; 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine |
| Molecular Formula | C21H14ClFN6 |
| Molecular Weight | 404.83 |
| Purity | ≥95 (HPLC) |
| Appearance | solid |
| Storage Condition | -20°C, sealed, dry |
| Application | Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor that plays an important role in regulating inflammatory responses and certain cancer treatments. |
| HTC | 2933990090 |
| MDL Number | MFCD12405303 |
| SMILES | Fc1c(cc(cc1)Nc2c3c(ncc2C#N)cnc(c3)NCc4cnccc4)Cl |
| InChI | 1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28) |
| InChI Key | NMEUKWOOQOHUNA-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/58641_1_871307_18_5.pdf |
| Use of | Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1]. Properties Name 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile Synonym More Synonyms TC-S 7006 Biological Activity Description Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1]. Related Catalog Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> MAP3K In Vitro Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1]. References [1]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60. Chemical & Physical Properties Exact Mass 404.09500 PSA 86.52000 LogP 5.19068 InChIKey NMEUKWOOQOHUNA-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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