| Chemical & Physical Properties | |
|---|---|
| CAS Number | 803712-79-0 |
| Catalog No. | 2A-9058233 |
| Chinese Name | 奥巴克拉甲磺酸盐 |
| Synonyms | Obatoclax Mesylate (GX15-070); Obatoclax Mesylate; Obatoclax mesilate; Obatoclax |
| Molecular Formula | C21H23N3O4S |
| Molecular Weight | 413.49 |
| Purity | ≥98 (HPLC) |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Obatoclax is an antagonist of BCL-2 family proteins. It binds BCL-2 with a Ki of 220 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD18074508 |
| SMILES | O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC |
| InChI | 1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-; |
| InChI Key | ZFKXDVMHNXPEIY-PEZBNFGJSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/58233_1_803712_79_0.pdf |
| Use of | Obatoclax is an antagonist of the BCL-2 family proteins. It binds to BCL-2 with a Ki of 220 nM. Properties Name 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate Synonym More Synonyms Obatoclax Mesylate Biological Activity Description Obatoclax is an antagonist of the BCL-2 family proteins. It binds to BCL-2 with a Ki of 220 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Bcl-2:220 nM (Ki) Bcl-xL:1-7 μM (Ki) Mcl-1:1-7 μM (Ki) Bcl-W:1-7 μM (Ki) Bcl-B:1-7 μM (Ki) References [1]. Marina Konopleva, et al. Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax). Cancer Res May 1, 2008 68; 3413 [2]. Wei WJ, et al. Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. Theranostics. 2017 Feb 23;7(4):987-1001. [3]. Or CR, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1). [4]. Champa D, et al. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget. 2016 Jun 7;7(23):34453-71. [5]. Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26. Chemical & Physical Properties Molecular Formula C21H23N3O4S Exact Mass 413.140930 PSA 115.92000 LogP 4.50730 InChIKey ZVAGBRFUYHSUHA-DJDCCMOGSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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