Home > Products > Specialty & Industrial Chemicals > Industrial Applications > trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

Name: trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid
Brand: 2A Biotech
SKU: 2A-9057949

CAS Number701232-20-4

Synonymscc-141; DGAT-3; trans-4-(4-(4-amino-7,7-dimethyl-7h-pyrimido(4,5-b)(1,4)oxazin-6-yl)phenyl)cyclohexaneacetic acid; T863

Molecular FormulaC22H26N4O3

Molecular Weight394.47

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point616.6±55.0 °C at 760 mmHg

Appearancepowder

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9057949 Purity: ≥98 (HPLC)%

Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Quality Control of [ 701232-20-4 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	701232-20-4
Catalog No.	2A-9057949
Chinese Name	反式-4-[4-(4-氨基-7,7-二甲基-7H-嘧啶并[4,5-B][1,4]噁唑-6-基)苯基]-环己基乙酰胺
Synonyms	cc-141; DGAT-3; trans-4-(4-(4-amino-7,7-dimethyl-7h-pyrimido(4,5-b)(1,4)oxazin-6-yl)phenyl)cyclohexaneacetic acid; T863
Molecular Formula	C22H26N4O3
Molecular Weight	394.47
Purity	≥98 (HPLC)
Density	1.4±0.1 g/cm3
Boiling Point	616.6±55.0 °C at 760 mmHg
Appearance	powder
Storage Condition	2-8℃
Application	T-863 is an orally active selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1). It can bind to the acyl-CoA binding site of DGAT1 and inhibit the synthesis of triacylglycerol in cells.
PubChem ID	329825541
MDL Number	MFCD11977270
SMILES	CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
InChI	1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI Key	FUIYMYNYUHVDPT-HDJSIYSDSA-N
NACRES Code	NA.77
UNSPSC	51111800
Hazard Symbols	transportation
MSDS	msds/57949_1_701232_20_4.pdf
Bioactivity	T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.IC50 value:Target: DGAT1T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Research Areas >> Metabolic Disease References [1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51. [2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5. [3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54( Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 616.6±55.0 °C at 760 mmHg Molecular Formula C22H26N4O3 Molecular Weight 394.467 Flash Point 326.7±31.5 °C Exact Mass 394.200500 PSA 110.69000 LogP 3.06 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.674 InChIKey FUIYMYNYUHVDPT-UHFFFAOYSA-N SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(C2CCC(CC(=O)O)CC2)cc1 Storage condition 2-8℃
Use of	Properties Name 2-[4-[4-(4-amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetic acid Synonym More Synonyms DGAT-3 Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Research Areas >> Metabolic Disease References [1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51. [2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5. [3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54( Chemical & Physical Properties Molecular Formula C22H26N4O3 Exact Mass 394.200500 PSA 110.69000 Index of Refraction 1.674 InChIKey FUIYMYNYUHVDPT-UHFFFAOYSA-N Storage condition 2-8℃
Transport Info	Shipping Name: UN
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.

Related Products in Industrial Applications
2,2-Difluorocyclopropylmethanol	509072-57-5	2A-9057518
[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methanol	635702-24-8	2A-9057765
[4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride	675198-19-3	2A-9057864
(3,3-Difluorocyclobutyl)methanol	681128-39-2	2A-9057899
3-(N,N-Diethanolamino)-L-alanine	700801-50-9	2A-9057946
cis-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid	701234-65-3	2A-9057950
(6-(1H-Pyrazol-1-yl)pyridin-3-yl)methanol	748796-38-5	2A-9058071
2-Amino-1-(3,4-dimethylphenyl)ethanol	786600-48-4	2A-9058185
3-(N-Ethanolamino)-L-alanine	848396-10-1	2A-9058337
Dichloro(1,1-bis(diphenylphosphino)ferrocene)palladium(II) acetone adduct	851232-71-8	2A-9058390
Browse all Industrial Applications products »

trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

Inquiry Form