![5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide structure, CAS 606143-52-6](/structures/60000/57684_1_606143_52_6.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 606143-52-6 |
| Catalog No. | 2A-9057684 |
| Chinese Name | 司美替尼 |
| Synonyms | AZD 6244; Selumetinib; AZD6244; ARRY-142886 |
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.68 |
| Purity | ≥98 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Selumetinib is a highly potent MEK inhibitor with an IC50 of 14 nM for MEK1 inhibition. |
| HTC | 2934999090 |
| MDL Number | MFCD11977472 |
| SMILES | Fc1c2nc[n](c2cc(c1Nc3c(cc(cc3)Br)Cl)C(=O)NOCCO)C |
| InChI | 1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChI Key | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/57684_1_606143_52_6.pdf |
| Use of | Selumetinib is a highly potent MEK inhibitor, with an IC50 of 14 nM against MEK1. Properties Name 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide Synonym More Synonyms Selumetinib (AZD6244) Biological Activity Description Selumetinib is a highly potent MEK inhibitor, with an IC50 of 14 nM against MEK1. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> MEK Research Areas >> Cancer MEK:12 nM (IC50) MEK1:14 nM (IC50) Cell Assay Primary HCC cells are plated at a density of 2.0×104 per well in growth medium. After 48 h in growth medium, the cell monolayer is rinsed twice with MEM. Cells are treated with various concentrations of Selumetinib (AZD6244, 0, 0.5, 1.0, 2.0, 3.0, and 4.0 μM) for 24 or 48 h. Cell viability is determined by the MTT assay. Cell proliferation is assayed using a bromodeoxyuridine kit as described by the manufacturer. Experiments are repeated at least thrice, and the data are expressed as mean±SE. References [1]. Huynh H, et al, Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Therapy, 2007, 6 (1), 138-146 [2]. Garon EB, et al. Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines. Mol Cancer Thera, 2010, 9 (7), 1985-1994. [4]. Sebolt-Leopold JS, et al. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer. 2004 Dec;4(12):937-47. [5]. Dela Cruz FS, et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8(1):116. [6]. Weisberg E, et al. Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R. Clin Cancer Res. 2014 Nov 1;20(21):5483-95. Chemical & Physical Properties Molecular Formula C17H15BrClFN4O3 Exact Mass 456.000000 PSA 88.41000 Index of Refraction 1.672 InChIKey CYOHGALHFOKKQC-UHFFFAOYSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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