| Chemical & Physical Properties | |
|---|---|
| CAS Number | 501948-05-6 |
| Catalog No. | 2A-9057483 |
| Chinese Name | 罗沙布林 |
| Synonyms | UNII-6Z674O12T6; Rosabulin; I01-9450; STA-5312 |
| Molecular Formula | C22H16O2N4S1 |
| Molecular Weight | 400.46 |
| Purity | 98.00 |
| Density | 1.34 |
| Melting Point | 233ºC |
| Storage Condition | 2-8℃ |
| Application | Rosabulin is a potent microtubule inhibitor with anti-tumor activity. |
| HTC | 2934999090 |
| MDL Number | MFCD13152388 |
| SMILES | Cc1cc(NC(=O)C(=O)c2cc(Cc3ccc(C#N)cc3)n3ccccc23)sn1 |
| InChI | InChI=1S/C22H16N4O2S/c1-14-10-20(29-25-14)24-22(28)21(27)18-12-17(26-9-3-2-4-19(18)26)11-15-5-7-16(13-23)8-6-15/h2-10,12H,11H2,1H3,(H,24,28) |
| InChI Key | IZZYUABKZYIINT-UHFFFAOYSA-N |
| MSDS | msds/57483_1_501948_05_6.pdf |
| Use of | Rosabulin is a potent microtubule inhibitor, with anti-cancer activities. Properties Name 2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide Synonym More Synonyms Rosabulin Biological Activity Description Rosabulin is a potent microtubule inhibitor, with anti-cancer activities. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer In Vitro Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1]. In Vivo Rosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1]. References [1]. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res, Volume 45, 2004 Chemical & Physical Properties Molecular Formula C22H16N4O2S Exact Mass 400.09900 PSA 115.50000 LogP 4.06108 Index of Refraction 1.7 InChIKey IZZYUABKZYIINT-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2934999090 Synthetic Route 3-Methylisothia... CAS#:24340-76-9 Oxalyl chloride CAS#:79-37-8 4-(indolizin-3-... CAS#:501948-43-2 CAS#:501948-05-6 p-Tolunitrile CAS#:104-85-8 CAS#:501948-05-6 Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250 4-(4-pyridin-2-... CAS#:501948-45-4 CAS#:501948-05-6 Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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