CAS Number500008-45-7
Synonyms3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl)pyrazole-5-carboxanilide; Chlorantraniliprole; DPX E2Y45; Chlorantranilipol; CHLOANTRANILIPROLE
Molecular FormulaC18H14BrCl2N5O2
Molecular Weight483.15
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point526.6±50.0 °C at 760 mmHg
Melting Point208 - 210 °C
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 500008-45-7 |
| Catalog No. | 2A-9057460 |
| Chinese Name | 氯虫苯甲酰胺 |
| Synonyms | 3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl)pyrazole-5-carboxanilide; Chlorantraniliprole; DPX E2Y45; Chlorantranilipol; CHLOANTRANILIPROLE |
| Molecular Formula | C18H14BrCl2N5O2 |
| Molecular Weight | 483.15 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 526.6±50.0 °C at 760 mmHg |
| Melting Point | 208 - 210 °C |
| Storage Condition | room temperature |
| Application | Chlorantraniliprole is an insecticide that can effectively and selectively activate ryanodine receptors. The EC50 values for the ryanodine receptors of Drosophila melanogaster and Spodoptera exigua |
| HTC | 2933399021 |
| PubChem ID | 329754259 |
| MDL Number | MFCD11840831 |
| SMILES | CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c2cc(Br)nn2-c3ncccc3Cl |
| InChI | 1S/C18H14BrCl2N5O2/c1-9-6-10(20)7-11(17(27)22-2)15(9)24-18(28)13-8-14(19)25-26(13)16-12(21)4-3-5-23-16/h3-8H,1-2H3,(H,22,27)(H,24,28) |
| InChI Key | PSOVNZZNOMJUBI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/57460_1_500008_45_7.pdf |
| Bioactivity | Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM). Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Target EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 μM (Ryanodine receptor, in C2C12 cells) In Vitro Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM)[1]. In Vivo Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day[1]. References [1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 526.6±50.0 °C at 760 mmHg Melting Point 208 - 210 °C Molecular Formula C18H14BrCl2N5O2 Molecular Weight 483.146 Flash Point 272.3±30.1 °C Exact Mass 480.970795 PSA 88.91000 LogP 5.55 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.699 InChIKey PSOVNZZNOMJUBI-UHFFFAOYSA-N SMILES CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl |
| Use of | Properties Name chlorantraniliprole Synonym More Synonyms chlorantraniliprole Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others References [1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279. Chemical & Physical Properties Molecular Formula C18H14BrCl2N5O2 Exact Mass 480.970795 PSA 88.91000 Index of Refraction 1.699 InChIKey PSOVNZZNOMJUBI-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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