| Chemical & Physical Properties | |
|---|---|
| CAS Number | 496775-61-2 |
| Catalog No. | 2A-9057446 |
| Chinese Name | 伊屈泼帕 |
| Synonyms | Eltrombopag; (E)-Eltrombopag; SB-497115-GR |
| Molecular Formula | C25H22N4O4 |
| Molecular Weight | 442.47 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 656.8±65.0 °C at 760 mmHg |
| Melting Point | 242-244ºC |
| Appearance | powder |
| Storage Condition | room temperature, dry |
| Application | Eltrombopag is a thrombopoietin (TPO) receptor agonist that treats certain conditions that cause thrombocytopenia. |
| HTC | 2933990090 |
| MDL Number | MFCD20926253 |
| SMILES | OC1=C(C=CC=C1N/N=C2C(C)=NN(C/2=O)C3=CC(C)=C(C=C3)C)C4=CC=CC(C(O)=O)=C4 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/57446_1_496775_61_2.pdf |
| Use of | Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia. Properties Name eltrombopag Synonym More Synonyms Eltrombopag Biological Activity Description Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Thrombopoietin Receptor Research Areas >> Cardiovascular Disease References [1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30. [2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93. [3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36. [5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45. Chemical & Physical Properties Molecular Formula C25H22N4O4 Exact Mass 442.164093 PSA 114.59000 Index of Refraction 1.667 Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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