CAS Number443913-73-3
SynonymsVandetanib; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; ZACTIMA; ZD 6474; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; Caprelsa; ZD6474; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Molecular FormulaC22H24BrFN4O2
Molecular Weight475.35
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point538.2±50.0 °C at 760 mmHg
Melting Point240-243ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 443913-73-3 |
| Catalog No. | 2A-9057221 |
| Chinese Name | 凡德他尼 |
| Synonyms | Vandetanib; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; ZACTIMA; ZD 6474; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; Caprelsa; ZD6474; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine |
| Molecular Formula | C22H24BrFN4O2 |
| Molecular Weight | 475.35 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 538.2±50.0 °C at 760 mmHg |
| Melting Point | 240-243ºC |
| Appearance | powder |
| Storage Condition | -20?C Freezer |
| Application | Vandetanib is a potent VEGFR2 inhibitor with an IC50 of 40 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD07772346 |
| SMILES | Fc1c(ccc(c1)Br)Nc2ncnc3c2cc(c(c3)OCC4CCN(CC4)C)OC |
| InChI | 1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) |
| InChI Key | UHTHHESEBZOYNR-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/57221_1_443913_73_3.pdf |
| Use of | Vandetanib is a potent inhibitor of VEGFR2 with an IC50 of 40 nM. Properties Name vandetanib Synonym More Synonyms Vandetanib(ZD6474) Biological Activity Description Vandetanib is a potent inhibitor of VEGFR2 with an IC50 of 40 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Research Areas >> Cancer VEGFR2:40 nM (IC50) References [1]. Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55. [3]. Takeda H, et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23. [4]. Inoue K, et al. Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33. Chemical & Physical Properties Molecular Formula C22H24BrFN4O2 Exact Mass 474.106659 PSA 59.51000 Index of Refraction 1.629 InChIKey UHTHHESEBZOYNR-UHFFFAOYSA-N Storage condition -20?C Freezer Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Formaldehyde CAS#:50-00-0 N-DeMethyl Vand... CAS#:338992-12-4 Vandetanib(ZD6474) CAS#:443913-73-3 Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226 Formaldehyde CAS#:50-00-0 TERT-BUTYL 4-((... CAS#:338992-20-4 Vandetanib(ZD6474) CAS#:443913-73-3 4-Bromo-2-fluor... CAS#:367-24-8 4-chloro-6-meth... CAS#:264208-72-2 Vandetanib(ZD6474) CAS#:443913-73-3 Literature: Marzaro, Giovanni; Guiotto, Adriano; Pastorini, Giovanni; Chilin, Adriana Tetrahedron, 2010 , vol. 66, # 4 p. 962 - 968 Precursor & DownStream Precursor 8 CAS#:50-00-0 Formaldehyde CAS#:338992-12-4 N-DeMethyl Vand... CAS#:338992-20-4 TERT-BUTYL 4-((... CAS#:367-24-8 4-Bromo-2-fluor... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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