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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide structure, CAS 439081-18-2

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

CAS Number439081-18-2

SynonymsAfatinib; Tovok; Tomtovok; BIBW2992; Gilotrif; BIBW 2992

Molecular FormulaC24H25ClFN5O3

Molecular Weight485.94

Purity98.00%

Density1.4±0.1 g/cm3

Boiling Point676.9±55.0 °C at 760 mmHg

Melting Point100 - 102 °C

Flash Point

Appearanceoff-white solid

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Cat. No.: 2A-9057185 Purity: 98.00%
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Quality Control of [ 439081-18-2 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number439081-18-2
Catalog No.2A-9057185
Chinese Name阿法替尼
SynonymsAfatinib; Tovok; Tomtovok; BIBW2992; Gilotrif; BIBW 2992
Molecular FormulaC24H25ClFN5O3
Molecular Weight485.94
Purity98.00
Density1.4±0.1 g/cm3
Boiling Point676.9±55.0 °C at 760 mmHg
Melting Point100 - 102 °C
Appearanceoff-white solid
Storage Condition-20°C
Application(E/Z)-Afatinib ((E/Z)-BIBW 2992) is a mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible EGFR inhibitor that blocks activation of EGFR, HER2, HER4 and EGFRvIII by irrever
HTC2934999090
MSDSmsds/57185_1_439081_18_2.pdf
Use of(E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1]. Properties Name Afatinib Synonym More Synonyms Afatinib (BIBW2992) Biological Activity Description (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> JAK/STAT Signaling >> EGFR Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR References [1]. Yoshioka T, et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr;109(4):1166-1176. [2]. Wang XK, et al. Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 2014 Dec 15;5(23):11971-85. [3]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. [4]. Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99. Chemical & Physical Properties Exact Mass 485.162994 PSA 88.61000 Index of Refraction 1.668 Safety Information Hazard Codes Xn HS Code 2934999090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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