CAS Number382180-17-8
SynonymsS2190_Selleck; N-Hydroxy-N'-3-pyridinyloctanediamide; N-Hydroxy-N'-(pyridin-3-yl)octanediamide; N1-Hydroxy-N8-3-pyridinyl-octanediamide; N-Hydroxy-N'-(3-pyridinyl)octanediamide; pyroxamide; N-Hydroxy-N'-3-pyridinyl octane diamide
Molecular FormulaC13H19N3O3
Molecular Weight265.31
Purity≥97 (HPLC)%
Density1.2±0.1 g/cm3
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 382180-17-8 |
| Catalog No. | 2A-9056973 |
| Chinese Name | N-羟基-N'-3-吡啶基辛二酰胺 |
| Synonyms | S2190_Selleck; N-Hydroxy-N'-3-pyridinyloctanediamide; N-Hydroxy-N'-(pyridin-3-yl)octanediamide; N1-Hydroxy-N8-3-pyridinyl-octanediamide; N-Hydroxy-N'-(3-pyridinyl)octanediamide; pyroxamide; N-Hydroxy-N'-3-pyridinyl octane diamide |
| Molecular Formula | C13H19N3O3 |
| Molecular Weight | 265.31 |
| Purity | ≥97 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Appearance | powder |
| Water Solubility | DMSO: soluble10mg/mL (clear solution) |
| Storage Condition | ?20°C |
| Application | Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide induces apoptosis and cell cycle arrest in leukemic cells. |
| HTC | 2933399090 |
| PubChem ID | 329825303 |
| MDL Number | MFCD13194970 |
| SMILES | ONC(=O)CCCCCCC(=O)Nc1cccnc1 |
| InChI | 1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18) |
| InChI Key | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/56973_1_382180_17_8.pdf |
| Use of | Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia. Properties Name N'-hydroxy-N-pyridin-3-yloctanediamide Synonym More Synonyms N-Hydroxy-N'-(3-pyridinyl)octanediamide Biological Activity Description Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC ID50: 100 nM[1] In Vitro Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1]. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1]. Cell Viability Assay[2] Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis[2] Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1 fractions at 48 hours compared with control samples. References [1]. Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7(4):962-70. [2]. Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9(15):5749-55. Chemical & Physical Properties Molecular Formula C13H19N3O3 Exact Mass 265.142639 PSA 91.32000 Appearance of Characters white to beige Index of Refraction 1.570 InChIKey PTJGLFIIZFVFJV-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302 Hazard Codes Xn Risk Phrases 22 RIDADR NONH for all modes of transport HS Code 2933399090 Synthetic Route Total: 1 Page 8-oxo-8-(3-pyri... CAS#:405096-07-3 N-Hydroxy-N'-(3... CAS#:382180-17-8 Literature: Remiszewski, Stacy W.; Sambucetti, Lidia C.; Atadja, Peter; Bair, Kenneth W.; Cornell, Wendy D.; Green, Michael A.; Howell, Kobporn Lulu; Jung, Manfred; Kwon, Paul; Trogani, Nancy; Walker, Heather Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 753 - 757 SUBERIC ACID MO... CAS#:3946-32-5 N-Hydroxy-N'-(3... CAS#:382180-17-8 Literature: Remiszewski, Stacy W.; Sambucetti, Lidia C.; Atadja, Peter; Bair, Kenneth W.; Cornell, Wendy D.; Green, Michael A.; Howell, Kobporn Lulu; Jung, Manfred; Kwon, Paul; Trogani, Nancy; Walker, Heather Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 753 - 757 Precursor & DownStream Precursor 2 CAS#:405096-07-3 8-oxo-8-(3-pyri... CAS#:3946-32-5 SUBERIC ACID MO... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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