CAS Number374750-30-8
Synonyms2`-C-Beta-Methyl Guanosine; 2'-METHYLGUANOSINE; 2'-C-Methylguanosine; 2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purin-6-ol
Molecular FormulaC11H15N5O5
Molecular Weight297.27
Purity98.00%
Density2.0±0.1 g/cm3
Boiling Point733.1±70.0 °C at 760 mmHg
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 374750-30-8 |
| Catalog No. | 2A-9056921 |
| Chinese Name | 2'-C-甲基鸟苷 |
| Synonyms | 2`-C-Beta-Methyl Guanosine; 2'-METHYLGUANOSINE; 2'-C-Methylguanosine; 2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purin-6-ol |
| Molecular Formula | C11H15N5O5 |
| Molecular Weight | 297.27 |
| Purity | 98.00 |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 733.1±70.0 °C at 760 mmHg |
| Appearance | solid |
| Water Solubility | H2O: soluble5mg/mL, clear (warmed) |
| Storage Condition | ?20°C |
| Application | 2'-Cmethylguanosine (2'-Cβ-methylguanosine) is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferon, producing antivira |
| PubChem ID | 329797236 |
| MDL Number | MFCD13194756 |
| SMILES | C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)CO)O)O |
| InChI | 1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1 |
| InChI Key | NVKAMPJSWMHVDK-GITKWUPZSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/56921_1_374750_30_8.pdf |
| Bioactivity | 2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 733.1±70.0 °C at 760 mmHg Molecular Formula C11H15N5O5 Molecular Weight 297.27 Flash Point 397.2±35.7 °C Exact Mass 297.107330 PSA 159.51000 LogP 0.34 Appearance of Characters white to beige Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.860 Storage condition ?20°C Water Solubility H2O: soluble5mg/mL, clear (warmed) |
| Use of | 2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. Properties Name 2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one Synonym More Synonyms 2'-C-Methylguanosine Biological Activity Description 2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. Chemical & Physical Properties Molecular Formula C11H15N5O5 Exact Mass 297.107330 PSA 159.51000 Appearance of Characters white to beige Index of Refraction 1.860 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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