CAS Number341028-37-3
SynonymsAlagebrium chloride (USAN); UNII-79QS8K2877; Alagebrium chloride; ALT-711; 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazol-3-ium chloride; 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride
Molecular FormulaC13H14O1N1Cl1S1
Molecular Weight267.78
Purity99.00%
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 341028-37-3 |
| Catalog No. | 2A-9056687 |
| Chinese Name | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 |
| Synonyms | Alagebrium chloride (USAN); UNII-79QS8K2877; Alagebrium chloride; ALT-711; 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazol-3-ium chloride; 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride |
| Molecular Formula | C13H14O1N1Cl1S1 |
| Molecular Weight | 267.78 |
| Purity | 99.00 |
| Storage Condition | room temperature, dry |
| Application | Alagebrium chloride is an advanced glycation end products (AGE) inhibitor. |
| HTC | 2934100090 |
| MDL Number | MFCD09027398 |
| SMILES | Cc1sc[n+](CC(=O)c2ccccc2)c1C.[Cl-] |
| InChI | InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1 |
| InChI Key | MKOMESMZHZNBIZ-UHFFFAOYSA-M |
| MSDS | msds/56687_1_341028_37_3.pdf |
| Use of | Alagebrium chloride is an advanced glycation end product (AGE) inhibitor. Properties Name 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone,chloride Synonym More Synonyms Alagebrium chloride Biological Activity Description Alagebrium chloride is an advanced glycation end product (AGE) inhibitor. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro Alagebrium chloride is an advanced glycation end product (AGE) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats[2]. In Vivo Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice[1]. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium[2]. References [1]. Watson AM, et al. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGEactivation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug;61(8):2105-13. [2]. Wang H, et al. Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40. Chemical & Physical Properties Exact Mass 267.04800 PSA 49.19000 InChIKey MKOMESMZHZNBIZ-UHFFFAOYSA-M Safety Information Hazard Codes Xi HS Code 2934100090 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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