![3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide structure, CAS 252003-65-9](/structures/60000/56009_1_252003_65_9.png)
CAS Number252003-65-9
Synonyms3-(4-Bromo-phenoxymethyl)-benzoic acid; 3-(4-Brom-benzyloxy)-benzoesaeure; CP-547632; 3-(4-bromo-benzyloxy)-benzoic acid
Molecular FormulaC20H24O3N5Br1S1F2
Molecular Weight532.41
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point548.6±50.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 252003-65-9 |
| Catalog No. | 2A-9056009 |
| Chinese Name | CP-547632 |
| Synonyms | 3-(4-Bromo-phenoxymethyl)-benzoic acid; 3-(4-Brom-benzyloxy)-benzoesaeure; CP-547632; 3-(4-bromo-benzyloxy)-benzoic acid |
| Molecular Formula | C20H24O3N5Br1S1F2 |
| Molecular Weight | 532.41 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 548.6±50.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, inert gas |
| Application | CP-547632 is a potent VEGFR2 and FGF2 kinase inhibitor with IC50 values of 11 and 9 nM, respectively. |
| HTC | 2934999090 |
| MDL Number | MFCD07772279 |
| SMILES | NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 |
| InChI Key | HXHAJRMTJXHJJZ-UHFFFAOYSA-N |
| MSDS | msds/56009_1_252003_65_9.pdf |
| Use of | CP-547632 is a potent inhibitor of the VEGFR2 and FGF2 kinases with IC50s of 11 and 9 nM, respectively. Properties Name 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Synonym More Synonyms CP-547632 Biological Activity Description CP-547632 is a potent inhibitor of the VEGFR2 and FGF2 kinases with IC50s of 11 and 9 nM, respectively. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Research Areas >> Cancer IC50: 11 nM (VEGFR2), 9 nM (FGF2)[1] In Vivo CP-547632 inhibits tumor-associated VEGFR-2 phosphorylation resulting in decreased microvascular density and significant tumor growth inhibition in a number of tumor models (EC50=590 ng/mL). CP-547632 is shown to inhibit VEGF-induced angiogenesis in vivo in a dose-responsive fashion[1]. References [1]. Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63(21):7301-9. Chemical & Physical Properties Molecular Formula C20H24BrF2N5O3S Exact Mass 531.075134 PSA 137.82000 Index of Refraction 1.622 InChIKey HXHAJRMTJXHJJZ-UHFFFAOYSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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