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Solifenacin succinate structure, CAS 242478-38-2

Solifenacin succinate

CAS Number242478-38-2

Synonyms(1R,3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; solifenacin succinate; Vesikur; Solifenacin succinate [USAN]; IsoprenalinoeSulfate; Vesicare; Solifenacin (Succinate)

Molecular FormulaC27H32O6N2

Molecular Weight480.56

Purity98.00%

Density1.24g/cm3

Boiling Point505.5ºC at 760 mmHg

Melting Point147 °C

Flash Point

AppearanceSolid;White to Almost white powder to crystal

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Cat. No.: 2A-9055925 Purity: 98.00%
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Quality Control of [ 242478-38-2 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number242478-38-2
Catalog No.2A-9055925
Chinese Name琥珀酸索利那新
Synonyms(1R,3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; solifenacin succinate; Vesikur; Solifenacin succinate [USAN]; IsoprenalinoeSulfate; Vesicare; Solifenacin (Succinate)
Molecular FormulaC27H32O6N2
Molecular Weight480.56
Purity98.00
Density1.24g/cm3
Boiling Point505.5ºC at 760 mmHg
Melting Point147 °C
AppearanceSolid;White to Almost white powder to crystal
Water SolubilityWater solubility: completely soluble; easily solub
Storage Conditionroom temperature, dry
ApplicationSolifenacin Succinate (YM905; Vesicare) is a muscarinic receptor antagonist.
MDL NumberMFCD00954234
SMILESO=C(O)CCC(=O)O.O=C(OC1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1
InChIInChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21?,22-;/m0./s1
InChI KeyRXZMMZZRUPYENV-VROPFNGYSA-N
MSDSmsds/55925_1_242478_38_2.pdf
BioactivitySolifenacin Succinate(YM905; Vesicare) is a muscarinic receptor antagonist.IC50 value:Target: muscarinic receptorSolifenacin succinate (YM905; Vesicare) is a prescription medication used to treat certain bladder problems. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Krishna SR, Rao BM, Rao NS.A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography.J Chromatogr Sci. 2010 Nov;48(10):807-10. [2]. Ohtake A, Sato S, Sasamata M, Miyata K.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes.J Pharmacol Sci. 2010;112(2):135-41. Epub 2010 Feb 4. [3]. Hoffstetter S, Leong FC.Solifenacin succinate for the treatment of overactive bladder.Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):345-50. [4]. Choo MS, Lee JZ, Lee JB, Kim YH, Jung HC, Lee KS, Kim JC, Seo JT, Paick JS, Kim HJ, Na YG, Lee JG.Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.Int J Clin Pract. 2008 Nov;62(11):1675-83. [5]. Imamura T, et al.Combined treatment with a β3 -adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats. Neurourol Urodyn. 2017 Apr;36(4):1026-1033. Chemical & Physical Properties Density 1.24g/cm3 Boiling Point 505.5ºC at 760 mmHg Melting Point 147 °C Molecular Formula C27H32N2O6 Molecular Weight 480.553 Flash Point 259.5ºC Exact Mass 480.226044 PSA 107.38000 LogP 3.67650 Vapour Pressure 2.41E-10mmHg at 25°C Index of Refraction 1.648 InChIKey RXZMMZZRUPYENV-VROPFNGYSA-N SMILES O=C(O)CCC(=O)O.O=C(OC1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1
Use ofSolifenacin Succinate(YM905; Vesicare) is a muscarinic receptor antagonist.IC50 value:Target: muscarinic receptorSolifenacin succinate (YM905; Vesicare) is a prescription medication used to treat certain bladder problems. Properties Name Solifenacin succinate Synonym More Synonyms solifenacin succinate Biological Activity Description Solifenacin Succinate(YM905; Vesicare) is a muscarinic receptor antagonist.IC50 value:Target: muscarinic receptorSolifenacin succinate (YM905; Vesicare) is a prescription medication used to treat certain bladder problems. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Krishna SR, Rao BM, Rao NS.A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography.J Chromatogr Sci. 2010 Nov;48(10):807-10. [2]. Ohtake A, Sato S, Sasamata M, Miyata K.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes.J Pharmacol Sci. 2010;112(2):135-41. Epub 2010 Feb 4. [3]. Hoffstetter S, Leong FC.Solifenacin succinate for the treatment of overactive bladder.Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):345-50. [4]. Choo MS, Lee JZ, Lee JB, Kim YH, Jung HC, Lee KS, Kim JC, Seo JT, Paick JS, Kim HJ, Na YG, Lee JG.Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.Int J Clin Pract. 2008 Nov;62(11):1675-83. [5]. Imamura T, et al.Combined treatment with a β3 -adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats. Neurourol Urodyn. 2017 Apr;36(4):1026-1033. Chemical & Physical Properties Molecular Formula C27H32N2O6 Exact Mass 480.226044 PSA 107.38000 LogP 3.67650 Index of Refraction 1.648 InChIKey RXZMMZZRUPYENV-VROPFNGYSA-N
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified solifenacin succinate
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