CAS Number236395-14-5
Synonyms(10S)-5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate; Exalief; EslicarbazepineAcetate; S-(−)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate; (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; Eslicarbazepine acetate; Aptiom; BIA 2-093; Zebinix; UNII-BEA68ZVB2K; Eslicarbazepine (acetate)
Molecular FormulaC17H16N2O3
Molecular Weight296.32
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point427.4±55.0 °C at 760 mmHg
Melting Point183-185ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 236395-14-5 |
| Catalog No. | 2A-9055898 |
| Chinese Name | 艾司利卡西平醋酸盐 |
| Synonyms | (10S)-5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate; Exalief; EslicarbazepineAcetate; S-(−)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate; (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; Eslicarbazepine acetate; Aptiom; BIA 2-093; Zebinix; UNII-BEA68ZVB2K; Eslicarbazepine (acetate) |
| Molecular Formula | C17H16N2O3 |
| Molecular Weight | 296.32 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 427.4±55.0 °C at 760 mmHg |
| Melting Point | 183-185ºC |
| Appearance | solid |
| Storage Condition | 0-10°C; avoid heating |
| Application | Eslicarbazepine acetate is an antiepileptic drug and a dual inhibitor of beta-secretase and voltage-gated sodium channels. |
| PubChem ID | 24891837 |
| MDL Number | MFCD06798333 |
| SMILES | CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c3ccccc13 |
| InChI | 1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1 |
| InChI Key | QIALRBLEEWJACW-INIZCTEOSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/55898_1_236395_14_5.pdf |
| Bioactivity | Eslicarbazepine acetate, an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel. Related Catalog Signaling Pathways >> Neuronal Signaling >> Beta-secretase Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease In Vivo Eslicarbazepine acetate is an antiepileptic drug. It is a prodrug which is activated to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine. Eslicarbazepine acetate is a prodrug for (S)-(+)-licarbazepine, the major active metabolite of oxcarbazepine. Its mechanism of action is therefore identical to that of oxcarbazepine. Eslicarbazepine acetate may not produce as high peak levels of (S)-(+)-licarbazepine immediately after dosing as does oxcarbazepine which could theoretically improve tolerability[1]. References [1]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 427.4±55.0 °C at 760 mmHg Melting Point 183-185ºC Molecular Formula C17H16N2O3 Molecular Weight 296.320 Flash Point 212.3±31.5 °C Exact Mass 296.116089 PSA 72.63000 LogP 1.70 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.655 InChIKey QIALRBLEEWJACW-INIZCTEOSA-N SMILES CC(=O)OC1Cc2ccccc2N(C(N)=O)c2ccccc21 |
| Use of | Eslicarbazepine acetate, an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel. Properties Name eslicarbazepine acetate Synonym More Synonyms Eslicarbazepine acetate Biological Activity Description Eslicarbazepine acetate, an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel. Related Catalog Signaling Pathways >> Neuronal Signaling >> Beta-secretase Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease In Vivo Eslicarbazepine acetate is an antiepileptic drug. It is a prodrug which is activated to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine. Eslicarbazepine acetate is a prodrug for (S)-(+)-licarbazepine, the major active metabolite of oxcarbazepine. Its mechanism of action is therefore identical to that of oxcarbazepine. Eslicarbazepine acetate may not produce as high peak levels of (S)-(+)-licarbazepine immediately after dosing as does oxcarbazepine which could theoretically improve tolerability[1]. References [1]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014. Chemical & Physical Properties Molecular Formula C17H16N2O3 Exact Mass 296.116089 PSA 72.63000 Index of Refraction 1.655 InChIKey QIALRBLEEWJACW-INIZCTEOSA-N |
| Transport Info | Product Name: Eslicarbazepine Acetate |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine | 231278-20-9 | 2A-9055878 |
| 4-Bromo-3,3,4,4-tetrafluorobutan-1-ol | 234443-21-1 | 2A-9055887 |
| 3,4,5-Trifluorobenzylamine | 235088-69-4 | 2A-9055890 |
| Micafungin | 235114-32-6 | 2A-9055893 |
| 2-[(1E,3E,5E)-6-(Dimethylamino)hexa-1,3,5-trienyl]-1,3,3-trimethyl-3H-indolium tetrafluoroborate | 235781-92-7 | 2A-9055894 |
| 1,4-Difluoro-2-(methylsulfonyl)benzene | 236739-03-0 | 2A-9055902 |
| 2-Methyl-4-heptafluoroisopropylaniline | 238098-26-5 | 2A-9055906 |
| Tosedostat | 238750-77-1 | 2A-9055909 |
| Fluopicolide | 239110-15-7 | 2A-9055913 |
| 6-Iodo-2-tetralone | 239783-48-3 | 2A-9055918 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS