| Chemical & Physical Properties | |
|---|---|
| CAS Number | 215923-54-9 |
| Catalog No. | 2A-9055630 |
| Chinese Name | 苯并二氧六环-6-(1-哌啶基)甲酰胺 |
| Synonyms | CX 546; Lopac-C-271; BDP 17; GR 87; CX546 |
| Molecular Formula | C14H17NO3 |
| Molecular Weight | 247.29 |
| Purity | ≥98 (HPLC) |
| Density | 1.215g/cm3 |
| Boiling Point | 422.8ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | 2-8℃ |
| Application | CX546 is a selective agonist of AMPAR receptors. |
| HTC | 2934999090 |
| PubChem ID | 24277960 |
| MDL Number | MFCD01860868 |
| SMILES | O=C(N1CCCCC1)c2ccc3OCCOc3c2 |
| InChI | 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2 |
| InChI Key | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/55630_1_215923_54_9.pdf |
| Use of | Properties Name 2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone Synonym More Synonyms CX546 Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21. [2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63. [3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85. [4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56. Chemical & Physical Properties Molecular Formula C14H17NO3 Exact Mass 247.12100 PSA 38.77000 LogP 2.02180 Index of Refraction 1.573 InChIKey LJUNPHMOGNFFOS-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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