CAS Number206986-87-0
SynonymsCholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,12α)- (1:1); (3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxycholan-24-oate de sodium; EINECS 206-643-5; Sodium (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate; Natrium-(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oat; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid sodium salt; MFCD00064138; cholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,8ξ,12α)- (1:1); Sodium cholate; Sodium cholate hydrate; (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid sodium salt; Cholalic acid sodium salt; Sodium (3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oate
Molecular FormulaC24H39NaO5
Molecular Weight430.55 (anhydrous basis)
Purity≥99%
Appearancepowder
EINECS206-643-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 206986-87-0 |
| Catalog No. | 2A-9055388 |
| Chinese Name | 胆酸钠 |
| Synonyms | Cholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,12α)- (1:1); (3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxycholan-24-oate de sodium; EINECS 206-643-5; Sodium (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate; Natrium-(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oat; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid sodium salt; MFCD00064138; cholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,8ξ,12α)- (1:1); Sodium cholate; Sodium cholate hydrate; (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid sodium salt; Cholalic acid sodium salt; Sodium (3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oate |
| Molecular Formula | C24H39NaO5 |
| Molecular Weight | 430.55 (anhydrous basis) |
| Purity | ≥99 |
| Appearance | powder |
| Storage Condition | Storage method: airtight, cool, ventilated and dry |
| Application | Sodium bile acid hydrate is the major primary bile acid produced in the liver, usually combined with glycine or taurine. Sodium cholate hydrate promotes fat absorption and cholesterol excretion. Sodiu |
| EINECS | 206-643-5 |
| HTC | 2918290000 |
| PubChem ID | 24892390 |
| MDL Number | MFCD00150749 |
| SMILES | O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C |
| InChI | 1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1 |
| InChI Key | MUVVIYFKOVLQHL-RCVKHMDESA-M |
| Beilstein/REAXYS | 3582354 |
| NACRES Code | NA.25 |
| UNSPSC | 12161900 |
| Hazard Symbols | transportation |
| MSDS | msds/55388_1_206986_87_0.pdf |
| Bioactivity | Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active[1][2]. Related Catalog Research Areas >> Metabolic Disease In Vitro Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. In Vivo Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2]. Animal Model: Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20-25 g)[2] Dosage: 1% (w/w) Cholic acid-supplemented diet Administration: Oral, 14 days Result: Decreases SHP expression and increased CYP2D6 activity. References [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. Chemical & Physical Properties Molecular Formula C24H39NaO5 Molecular Weight 430.553 Exact Mass 430.269531 PSA 100.82000 LogP 2.11400 InChIKey QWSPGAWHPXZHEP-RCVKHMDESA-N SMILES CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.O.[Na] |
| Use of | Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active[1][2]. Properties Name sodium,(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate Synonym More Synonyms Sodium cholate Biological Activity Description Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active[1][2]. Related Catalog Research Areas >> Metabolic Disease References [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. Chemical & Physical Properties Molecular Formula C24H39NaO5 Exact Mass 430.269531 PSA 100.82000 LogP 2.11400 InChIKey QWSPGAWHPXZHEP-RCVKHMDESA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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