| Chemical & Physical Properties | |
|---|---|
| CAS Number | 204205-90-3 |
| Catalog No. | 2A-9055303 |
| Chinese Name | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 |
| Synonyms | 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide; ZIO-301; Indibulin; 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(4-pyridinyl)acetamide |
| Molecular Formula | C22H16O2N3Cl1 |
| Molecular Weight | 389.84 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Storage Condition | Desiccate at -20°C |
| Application | Indibulin (ZIO 301), an orally available inhibitor of tubulin synthesis, has good anticancer activity and minimal neurotoxicity. Indibulin reduces myenteric nerve tone, produces abnormal spindles, act |
| HTC | 2933399090 |
| MDL Number | MFCD05861105 |
| SMILES | O=C(Nc1ccncc1)C(=O)c1cn(Cc2ccc(Cl)cc2)c2ccccc12 |
| InChI | InChI=1S/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28) |
| InChI Key | SOLIIYNRSAWTSQ-UHFFFAOYSA-N |
| MSDS | msds/55303_1_204205_90_3.pdf |
| Use of | Indibulin (ZIO 301) , an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1]. Properties Name 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide Synonym More Synonyms Indibulin Biological Activity Description Indibulin (ZIO 301) , an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease Tubulin[1] References Chemical & Physical Properties Exact Mass 389.093109 PSA 63.99000 Index of Refraction 1.665 InChIKey SOLIIYNRSAWTSQ-UHFFFAOYSA-N Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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