CAS Number303-26-4
SynonymsEINECS 206-137-4; N-(4-CHLOROBENZHYDRYL)-PIPERAZINE; 1-(α-Phenyl-4-chlorobenzyl)piperazine; Norchlorcyclizine; 1-(4-Chlorobenzhydry)piperazine; 1-((4-Chlorophenyl)(phenyl)methyl)piperazine; 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; 1-(4-Chlorobenzhydryl) piperazine; 1-(4-Chloro-α-phenylbenzyl)piperazine; 1-(p-chlorobenzhydryl)piperazine; N-[(4-chlorophenyl)phenylmethyl]piperazine; 1-(4-Chlorodiphenylmethyl)piperazine; 1-(4-chlorobenzhydryl)-piperazine; 1-(4-chlorobenzhydryl); N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine; MFCD00005965; UNII:T875VN0D6E; 4-(4-Chlorobenzhydryl)piperazine; (RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine; 1-[(4-chlorophenyl)phenylmethyl]-piperazine
Molecular FormulaC17H19ClN2
Molecular Weight286.80
Purity90%
Density1.2±0.1 g/cm3
Boiling Point178-180 °C/0.5 mmHg (lit.)
Melting Point65-70 °C (lit.)
Appearancepowder
EINECS206-137-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 303-26-4 |
| Catalog No. | 2A-9000537 |
| Chinese Name | 1-(4-氯二苯基)哌嗪 |
| Synonyms | EINECS 206-137-4; N-(4-CHLOROBENZHYDRYL)-PIPERAZINE; 1-(α-Phenyl-4-chlorobenzyl)piperazine; Norchlorcyclizine; 1-(4-Chlorobenzhydry)piperazine; 1-((4-Chlorophenyl)(phenyl)methyl)piperazine; 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; 1-(4-Chlorobenzhydryl) piperazine; 1-(4-Chloro-α-phenylbenzyl)piperazine; 1-(p-chlorobenzhydryl)piperazine; N-[(4-chlorophenyl)phenylmethyl]piperazine; 1-(4-Chlorodiphenylmethyl)piperazine; 1-(4-chlorobenzhydryl)-piperazine; 1-(4-chlorobenzhydryl); N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine; MFCD00005965; UNII:T875VN0D6E; 4-(4-Chlorobenzhydryl)piperazine; (RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine; 1-[(4-chlorophenyl)phenylmethyl]-piperazine |
| Molecular Formula | C17H19ClN2 |
| Molecular Weight | 286.80 |
| Purity | 90 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 178-180 °C/0.5 mmHg (lit.) |
| Melting Point | 65-70 °C (lit.) |
| Appearance | powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Refrigerator |
| Application | 1-(4-Chlorobenzaldehyde)piperazine is a biochemical reagent that can be used as a biological material or organic compound in life science-related research. |
| EINECS | 206-137-4 |
| HTC | 2933599090 |
| PubChem ID | 24892489 |
| MDL Number | MFCD00005965 |
| SMILES | Clc1ccc(cc1)C(N2CCNCC2)c3ccccc3 |
| InChI | 1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2 |
| InChI Key | UZKBSZSTDQSMDR-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | R36/37/38 |
| Safety Description | S24/25 |
| MSDS | msds/537_1_303_26_4.pdf |
| Bioactivity | 1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others In Vitro 1-(4-Chlorobenzhydryl)piperazine is an inactive metabolite of mechlorazine and chlorcycline and is an impurity found in commercial formulations of hydroxyzine and cetirizine. 1-(4-Chlorobenzyl)piperazine has been used in the synthesis of voltage-gated sodium channel 1.7 (Nav1.7) inhibitors, anticancer agents, and antihistamines. References [1]. Gaertner, HJ, Breyer, U., and Liomin, G. Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm. Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538-541 (2012) Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 409.1±0.0 °C at 760 mmHg Melting Point 65-70 °C(lit.) Molecular Formula C17H19ClN2 Molecular Weight 286.80 Flash Point 193.3±26.5 °C Exact Mass 286.123688 PSA 15.27000 LogP 3.44 Vapor Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.592 InChIKey UZKBSZSTDQSMDR-UHFFFAOYSA-N SMILES Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1 Storage condition Refrigerator |
| Use of | 1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Properties Name 1-(4-Chlorobenzhydryl)piperazine Synonym More Synonyms UNII:T875VN0D6E Biological Activity Description 1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others In Vitro 1-(4-chlorobenzyl)piperazine is an inactive metabolite of mechlorazine and chlorcycline and is an impurity found in commercial formulations of hydroxyzine and cetirizine. 1-(4-Chlorobenzyl)piperazine has been used in the synthesis of voltage-gated sodium channel 1.7 (Nav1.7) inhibitors, anticancer agents, and antihistamines. References [1]. Gaertner, HJ, Breyer, U., and Liomin, G. Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm. Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012) Chemical & Physical Properties Exact Mass 286.123688 PSA 15.27000 Index of Refraction 1.592 InChIKey UZKBSZSTDQSMDR-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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