CAS Number132810-10-7
Synonyms2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; Lonasen; Blonanserin
Molecular FormulaC23H30FN3
Molecular Weight367.50
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point540.8±50.0 °C at 760 mmHg
Melting Point117-119°C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 132810-10-7 |
| Catalog No. | 2A-9052234 |
| Chinese Name | 布南色林 |
| Synonyms | 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; Lonasen; Blonanserin |
| Molecular Formula | C23H30FN3 |
| Molecular Weight | 367.50 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 540.8±50.0 °C at 760 mmHg |
| Melting Point | 117-119°C |
| Appearance | powder |
| Water Solubility | DMSO: ≥10mg/mL |
| Storage Condition | Refrigerator |
| Application | Blonanserin (AD-5423) is a D2/5-HT2 receptor antagonist. |
| PubChem ID | 329773292 |
| MDL Number | MFCD00893838 |
| SMILES | CCN1CCN(CC1)c2cc(-c3ccc(F)cc3)c4CCCCCCc4n2 |
| InChI | 1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3 |
| InChI Key | XVGOZDAJGBALKS-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/52234_1_132810_10_7.pdf |
| Bioactivity | Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic. Target: D2 receptor; 5-HT2 receptorBlonanserin(AD-5423) is a relatively new atypical antipsychotic for the treatment of schizophrenia. Blonanserin belongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines and acts as an antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors. Blonanserin has low affinity for 5-HT2C, adrenergic α1, histamine H1, and muscarinic M1 receptors, but displays relatively high affinity for 5-HT6 receptors [1]. AD-5423 bound preferentially to dopamine (DA)-D2 (Ki, 14.8 nM; cf. haloperidol, 8.79 nM; and clozapine, 149 nM) and serotonin (5-HT)-S2 (Ki, 3.98 nM; cf. haloperidol, 26.8 nM; and clozapine, 8.66 nM) receptors. It displayed low affinity for adrenaline (Ad)-alpha-1 (Ki, 56.3 nM) receptors and was virtually devoid of binding to DA-D1 (Ki, 2870 nM), 5-HT-S3, Ad-alpha-2, Ad-beta, muscarine, tau-aminobutyric acid and benzodiazepine receptors. In addition, AD-5423 was only a weak inhibitor of DA, 5-HT and noradrenaline uptake systems. AD-5423 (0.2-2 mg/kg p.o.) decreased exploratory activity in mice. AD-5423 (10 mg/kg p.o.), unlike haloperidol, did not antagonize SKF38393-induced vacuous oral movements in rats. Head twitches induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane in mice and by para-chloroamphetamine in rats were antagonized by AD-5423 at much lower doses (0.5-2 mg/kg p.o.) than those of haloperidol and clozapine [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Tenjin, T., et al., Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr Dis Treat, 2013. 9: p. 587-94. [2]. Oka, M., et al., Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties. J Pharmacol Exp Ther, 1993. 264(1): p. 158-65. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 540.8±50.0 °C at 760 mmHg Melting Point 117-119°C Molecular Formula C23H30FN3 Molecular Weight 367.503 Flash Point 280.9±30.1 °C Exact Mass 367.242371 PSA 19.37000 LogP 6.03 Appearance of Characters white to off-white Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.557 InChIKey XVGOZDAJGBALKS-UHFFFAOYSA-N SMILES CCN1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)CCCCCC3)CC1 Storage condition Refrigerator Water Solubility DMSO: ≥10mg/mL |
| Use of | Properties Articles25 Name Blonanserin Synonym More Synonyms Blonanserin Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Tenjin, T., et al., Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr Dis Treat, 2013. 9: p. 587-94. [2]. Oka, M., et al., Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties. J Pharmacol Exp Ther, 1993. 264(1): p. 158-65. Chemical & Physical Properties Molecular Formula C23H30FN3 Exact Mass 367.242371 PSA 19.37000 Appearance of Characters white to off-white Index of Refraction 1.557 InChIKey XVGOZDAJGBALKS-UHFFFAOYSA-N Storage condition Refrigerator |
| Transport Info | Product Name: Bunanselin |
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