CAS Number123524-52-7
SynonymsAzelnidipine; UNII:PV23P19YUG; 3,5-Pyridinedicarboxylic acid (2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl); MFCD00865803
Molecular FormulaC33H34N4O6
Molecular Weight582.646
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point709.3±60.0 °C at 760 mmHg
Melting Point120-126ºC
AppearanceLight yellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 123524-52-7 |
| Catalog No. | 2A-9051578 |
| Chinese Name | 阿折地平 |
| Synonyms | Azelnidipine; UNII:PV23P19YUG; 3,5-Pyridinedicarboxylic acid (2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl); MFCD00865803 |
| Molecular Formula | C33H34N4O6 |
| Molecular Weight | 582.646 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 709.3±60.0 °C at 760 mmHg |
| Melting Point | 120-126ºC |
| Appearance | Light yellow powder |
| Water Solubility | Water solubility: insoluble; easily soluble in: ac |
| Storage Condition | Room temp |
| Application | Azelnidipine (CS 905; Calblock) is a dihydropyridine derivative, an L-type calcium channel blocker, and can fight hypertension. |
| HTC | 2933990090 |
| SMILES | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 |
| InChI | InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3 |
| InChI Key | ZKFQEACEUNWPMT-UHFFFAOYSA-N |
| Bioactivity | Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.IC50 value:Target: L-type calcium channelAcute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Komoda H, Inoue T, Node K. Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker. Clin Exp Hypertens. 2010 Jan;32(2):121-8. [2]. Kain V, Kumar S, Sitasawad SL. Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis. Cardiovasc Diabetol. 2011 Nov 4;10:97. [3]. Takano Y, Ueyama T, Ishikura F. Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like α·β blocker. J Cardiol. 2012 Jul;60(1):18-22. [4]. Shimizu T, Tanaka T, Iso T et al. Azelnidipine inhibits MSX2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells. Int Heart J. 2012;53(5):331-5. [5]. Ohyama T, Sato K, Kishimoto K et al. Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. Br J Pharmacol. 2012 Feb;165(4b):1173-87. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 709.3±60.0 °C at 760 mmHg Melting Point 120-126ºC Molecular Formula C33H34N4O6 Molecular Weight 582.646 Flash Point 382.8±32.9 °C Exact Mass 582.247864 PSA 139.71000 LogP 4.21 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.659 InChIKey ZKFQEACEUNWPMT-UHFFFAOYSA-N SMILES CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 Storage condition Room temp |
| Use of | Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.IC50 value:Target: L-type calcium channelAcute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis. Properties Articles32 Name Azelnidipine Synonym More Synonyms Azelnidipine Biological Activity Description Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.IC50 value:Target: L-type calcium channelAcute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Komoda H, Inoue T, Node K. Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker. Clin Exp Hypertens. 2010 Jan;32(2):121-8. [2]. Kain V, Kumar S, Sitasawad SL. Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis. Cardiovasc Diabetol. 2011 Nov 4;10:97. [3]. Takano Y, Ueyama T, Ishikura F. Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like α·β blocker. J Cardiol. 2012 Jul;60(1):18-22. [4]. Shimizu T, Tanaka T, Iso T et al. Azelnidipine inhibits MSX2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells. Int Heart J. 2012;53(5):331-5. [5]. Ohyama T, Sato K, Kishimoto K et al. Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. Br J Pharmacol. 2012 Feb;165(4b):1173-87. Chemical & Physical Properties Molecular Formula C33H34N4O6 Exact Mass 582.247864 PSA 139.71000 Index of Refraction 1.659 InChIKey ZKFQEACEUNWPMT-UHFFFAOYSA-N Storage condition Room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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