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Isopropyl unoprostone structure, CAS 120373-24-2

Isopropyl unoprostone

CAS Number120373-24-2

SynonymsMFCD00886951; Unoprostone Isopropyl; Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate; Unoprostone Isopropyl Ester; Isopropyl unoprostone

Molecular FormulaC25H44O5

Molecular Weight424.614

Purity98.00%

Density1.0±0.1 g/cm3

Boiling Point546.3±45.0 °C at 760 mmHg

Melting Point

Flash Point

Appearance

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Cat. No.: 2A-9051343 Purity: 98.00%
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Quality Control of [ 120373-24-2 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number120373-24-2
Catalog No.2A-9051343
Chinese Name乌诺前列酮异丙酯
SynonymsMFCD00886951; Unoprostone Isopropyl; Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate; Unoprostone Isopropyl Ester; Isopropyl unoprostone
Molecular FormulaC25H44O5
Molecular Weight424.614
Purity98.00
Density1.0±0.1 g/cm3
Boiling Point546.3±45.0 °C at 760 mmHg
Storage Condition-20°C Freezer
ApplicationIsopropyl nonprostone (nonprostone isopropyl ester) is an analogue of a prostaglandin metabolite and a potent activator of large-conductance calcium-activated potassium (BK) channels. Isopropyl unopro
SMILESCCCCCCCC(=O)CCC1C(O)CC(O)C1CC=CCCCC(=O)OC(C)C
InChIInChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1
InChI KeyXXUPXHKCPIKWLR-JHUOEJJVSA-N
Hazard Symbolstransportation
BioactivityIsopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Target BK channels[1] In Vitro Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H2O2-induced 661W cell death[2]. Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death[2]. Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells[2]. Apoptosis Analysis[2] Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then added H2O2) Concentration: 0.01, 0.1 and 1 μM Incubation Time: 24 h Result: Protected against H2O2-induced cell death in a concentration-dependent manner. Apoptosis Analysis[2] Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then exposed to 2,500 lux of white fluorescent light) Concentration: 0.1, 1 and 3 μM Incubation Time: 24 h Result: Protected against light-induced cell death in a concentration-dependent manner, and the effect was significant at the 1 and 3 μM concentrations; reduced the morphological change (the transition to a rounder shape) which is potentially indicative of a pre-apoptotic stage. References [1]. Haria M, et al. Unoprostone (isopropyl unoprostone). Drugs Aging. 1996 Sep;9(3):213-8; discussion 219-20. [2]. Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 546.3±45.0 °C at 760 mmHg Molecular Formula C25H44O5 Molecular Weight 424.614 Flash Point 172.2±22.2 °C Exact Mass 424.318878 PSA 83.83000 LogP 4.63 Vapour Pressure 0.0±3.3 mmHg at 25°C Index of Refraction 1.492 InChIKey XXUPXHKCPIKWLR-JHUOEJJVSA-N SMILES CCCCCCCC(=O)CCC1C(O)CC(O)C1CC=CCCCC(=O)OC(C)C Storage condition -20°C Freezer
Use ofIsopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2]. Properties Name isopropyl unoprostone Synonym More Synonyms Isopropyl unoprostone Biological Activity Description Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel BK channels[1] References [1]. Haria M, et al. Unoprostone (isopropyl unoprostone). Drugs Aging. 1996 Sep;9(3):213-8; discussion 219-20. [2]. Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65. Chemical & Physical Properties Molecular Formula C25H44O5 Exact Mass 424.318878 PSA 83.83000 Index of Refraction 1.492 InChIKey XXUPXHKCPIKWLR-JHUOEJJVSA-N
Transport InfoProduct name: Purity: 95.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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