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Bisindolylmaleimide IV structure, CAS 119139-23-0

Bisindolylmaleimide IV

CAS Number119139-23-0

SynonymsMFCD00236432; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 2,3-bis-(1h-indol-3-yl)-maleimide; 3,4-Bis(3-indolyl)maleimide; 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Molecular FormulaC20H13N3O2

Molecular Weight327.34

Purity≥98 (TLC)%

Density1.5±0.1 g/cm3

Boiling Point690.1±55.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

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Cat. No.: 2A-9051241 Purity: ≥98 (TLC)%
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Quality Control of [ 119139-23-0 ] Purity: ≥98 (TLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number119139-23-0
Catalog No.2A-9051241
Chinese Name二吲哚马来酰亚胺IV
SynonymsMFCD00236432; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 2,3-bis-(1h-indol-3-yl)-maleimide; 3,4-Bis(3-indolyl)maleimide; 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular FormulaC20H13N3O2
Molecular Weight327.34
Purity≥98 (TLC)
Density1.5±0.1 g/cm3
Boiling Point690.1±55.0 °C at 760 mmHg
Appearancepowder
Storage ConditionSeal and store at -20ºC
ApplicationBisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor with an IC50 ranging from 0.1-0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8 μM). Bisindolylmalei
HTC2933990090
MDL NumberMFCD00236432
SMILESN1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
InChI1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI KeyDQYBRTASHMYDJG-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352111
Hazard Symbolstransportation
MSDSmsds/51241_1_119139_23_0.pdf
BioactivityBisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> CMV Target PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50) In Vitro Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1]. References [1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. [2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 690.1±55.0 °C at 760 mmHg Molecular Formula C20H13N3O2 Molecular Weight 327.336 Flash Point 371.2±31.5 °C Exact Mass 327.100769 PSA 77.75000 LogP 3.21 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.811 InChIKey DQYBRTASHMYDJG-UHFFFAOYSA-N SMILES O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12 Storage condition -20℃
Use ofBisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2]. Properties Articles29 Name Bisindolylmaleimide IV Synonym More Synonyms Bisindolylmaleimide IV Biological Activity Description Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> CMV PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50) In Vitro Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1]. References [1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. [2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74. Chemical & Physical Properties Molecular Formula C20H13N3O2 Exact Mass 327.100769 PSA 77.75000 Index of Refraction 1.811 InChIKey DQYBRTASHMYDJG-UHFFFAOYSA-N Storage condition -20℃
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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