CAS Number114676-69-6
Synonyms1-O-tert-butyl 2-O-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate; Methyl Cis-1-Boc-4-Hydroxy-D-Prolinate; N-Boc-cis-4-hydroxy-D-proline methyl ester
Molecular FormulaC11H19O5N1
Molecular Weight245.28
Purity98.00%
Density1.216g/cm3
Boiling Point335.2ºC at 760mmHg
Melting Point80 °C
AppearancePowder | White
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 114676-69-6 |
| Catalog No. | 2A-9050842 |
| Chinese Name | 顺式-1-N-叔丁氧羰基-4-羟基-D-脯氨酸甲酯 |
| Synonyms | 1-O-tert-butyl 2-O-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate; Methyl Cis-1-Boc-4-Hydroxy-D-Prolinate; N-Boc-cis-4-hydroxy-D-proline methyl ester |
| Molecular Formula | C11H19O5N1 |
| Molecular Weight | 245.28 |
| Purity | 98.00 |
| Density | 1.216g/cm3 |
| Boiling Point | 335.2ºC at 760mmHg |
| Melting Point | 80 °C |
| Appearance | Powder | White |
| Storage Condition | room temperature |
| Application | N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also an alkyl chain-based P |
| HTC | 2933990090 |
| MDL Number | MFCD00797548 |
| MSDS | msds/50842_1_114676_69_6.pdf |
| Bioactivity | N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.216g/cm3 Boiling Point 335.2ºC at 760mmHg Melting Point 80 °C Molecular Formula C11H19NO5 Molecular Weight 245.27200 Flash Point 156.6ºC Exact Mass 245.12600 PSA 76.07000 LogP 0.46760 Appearance of Characters Powder | White Vapour Pressure 8.47E-06mmHg at 25°C Index of Refraction 1.5 |
| Use of | N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Properties Name Methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate Synonym More Synonyms Biological Activity Description N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C11H19NO5 Exact Mass 245.12600 PSA 76.07000 LogP 0.46760 Appearance of Characters Powder | White Index of Refraction 1.5 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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