CAS Number110871-86-8
SynonymsSparcin; PD 1315-1; Zagam; at4140; SULFAMIC ACID; SPARFLOXACIN (BASE AND/OR UNSPECIFIED SALTS); Spara; ci978; MFCD00869619; Sparfloxacin; Sparfloxaci; Parox
Molecular FormulaC19H22F2N4O3
Molecular Weight392.41
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point640.4±55.0 °C at 760 mmHg
Melting Point265°C
AppearanceLight yellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 110871-86-8 |
| Catalog No. | 2A-9050550 |
| Chinese Name | 司帕沙星 |
| Synonyms | Sparcin; PD 1315-1; Zagam; at4140; SULFAMIC ACID; SPARFLOXACIN (BASE AND/OR UNSPECIFIED SALTS); Spara; ci978; MFCD00869619; Sparfloxacin; Sparfloxaci; Parox |
| Molecular Formula | C19H22F2N4O3 |
| Molecular Weight | 392.41 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 640.4±55.0 °C at 760 mmHg |
| Melting Point | 265°C |
| Appearance | Light yellow powder |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | Sparfloxacin is a fluoroquinolone antibiotic. |
| MDL Number | C19H22F2N4O3 |
| SMILES | CC1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC(C)N1 |
| InChI Key | DZZWHBIBMUVIIW-DTORHVGOSA-N |
| MSDS | msds/50550_1_110871_86_8.pdf |
| Bioactivity | Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.Target: AntibacterialSparfloxacin shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice [1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Nakamura, S., et al., In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone. Antimicrob Agents Chemother, 1989. 33(8): p. 1167-73. [2]. Pan, X.S. and L.M. Fisher, Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob Agents Chemother, 1997. 41(2): p. 471-4. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 640.4±55.0 °C at 760 mmHg Melting Point 265°C Molecular Formula C19H22F2N4O3 Molecular Weight 392.400 Flash Point 341.1±31.5 °C Exact Mass 392.165985 PSA 100.59000 LogP 1.20 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.627 InChIKey DZZWHBIBMUVIIW-DTORHVGOSA-N SMILES CC1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC(C)N1 Storage condition Store at 0-5°C |
| Use of | Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.Target: AntibacterialSparfloxacin shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice [1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis [2]. Properties Articles47 Name sparfloxacin Synonym More Synonyms Sparfloxacin Biological Activity Description Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.Target: AntibacterialSparfloxacin shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice [1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Nakamura, S., et al., In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone. Antimicrob Agents Chemother, 1989. 33(8): p. 1167-73. [2]. Pan, X.S. and L.M. Fisher, Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob Agents Chemother, 1997. 41(2): p. 471-4. Chemical & Physical Properties Molecular Formula C19H22F2N4O3 Exact Mass 392.165985 PSA 100.59000 Index of Refraction 1.627 InChIKey DZZWHBIBMUVIIW-DTORHVGOSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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