CAS Number110078-46-1
SynonymsPlerixafor; Sdz sid 791; 1,1'-[1,4-Phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane); 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]; Mozobil; AMD3100
Molecular FormulaC28H54N8
Molecular Weight502.78
Purity98.00%
Density1.0±0.1 g/cm3
Boiling Point657.5±55.0 °C at 760 mmHg
Melting Point122-125°C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 110078-46-1 |
| Catalog No. | 2A-9050485 |
| Chinese Name | 普乐沙福 |
| Synonyms | Plerixafor; Sdz sid 791; 1,1'-[1,4-Phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane); 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]; Mozobil; AMD3100 |
| Molecular Formula | C28H54N8 |
| Molecular Weight | 502.78 |
| Purity | 98.00 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 657.5±55.0 °C at 760 mmHg |
| Melting Point | 122-125°C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Refrigerator |
| Application | Plerixafor is a selective CXCR4 antagonist with an IC50 value of 44 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD05662218 |
| SMILES | N3(CCNCCCNCCNCCC3)Cc1ccc(cc1)CN2CCNCCCNCCNCCC2 |
| InChI | 1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2 |
| InChI Key | YIQPUIGJQJDJOS-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/50485_1_110078_46_1.pdf |
| Use of | Plerixafor is a selective CXCR4 antagonist with an IC50 of 44 nM. Properties Name Plerixafor Synonym More Synonyms Plerixafor (AMD3100) Biological Activity Description Plerixafor is a selective CXCR4 antagonist with an IC50 of 44 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Inflammation/Immunology 125I-CXCL12-CXCR4:44 nM (IC50) In Vitro The CXCR4 inhibitor Plerixafor (AMD3100) is a potent inhibitor of CXCL12-mediated chemotaxis (IC50, 5.7 nM) with a potency slightly better than its affinity for CXCR4. Treating the cells with CCX771 or CXCL11 has no effect on CXCL12-mediated MOLT-4 or U937 TEM. In contrast, 10 μM Plerixafor inhibits CXCL12-mediated TEM in both cells lines[1]. Plerixafor (10 μM)-treated cells show a moderate reduction in cell proliferation compared to CXCL12-stimulated cells, which do not reach statistical significance[2]. References [2]. Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55. [3]. Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926. [4]. Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10(7):e0133616. [5]. He G, et al. SDF-1 in Mammary Fibroblasts of Bovine with Mastitis Induces EMT and Inflammatory Response of Epithelial Cells. Int J Biol Sci. 2017 May 5;13(5):604-614. [6]. Wei He, et al. Targeting CXC motif chemokine receptor 4 inhibits the proliferation, migration and angiogenesis of lung cancer cells. Oncol Lett. 2018 Sep;16(3):3976-3982. Chemical & Physical Properties Molecular Formula C28H54N8 Exact Mass 502.447144 PSA 78.66000 Index of Refraction 1.492 InChIKey YIQPUIGJQJDJOS-UHFFFAOYSA-N Storage condition Refrigerator Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 1,1'-[1,4-P... 406939-93-3 Plerixafor (AMD... 110078-46-1 175854-48-5 Plerixafor (AMD... 110078-46-1 Literature: Brandes, Stephane Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 1 p. 65 - 73 1,4-Bis(bromome... Plerixafor (AMD... 110078-46-1 Literature: Journal of Organic Chemistry, , vol. 70, # 18 p. 7042 - 7053 Precursor & DownStream Precursor 7 CAS#:623-24-5 1,4-Bis(bromome... CAS#:295-37-4 1,4,8,11-Tetraa... CAS#:439211-82-2 (R)-N-(1-phenyl... CAS#:74199-16-9 1H,6H-3a,5a,8a,... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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