CAS Number108341-18-0
SynonymsNorepinephrine Bitartrate; L-Arterenol Bitartrate Monohydrate; (2R,3R)-2,3-Dihydroxysuccinic acid - 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol (1:1); MFCD00150449; 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1); L-(-)-Norepinephrine (+)-bitartrate salt monohydrate; 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1); L-Norepinephrine Bitartrate Monohydrate; Noradrenaline bitartrate monohydrate; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt); L-Norepinephrine Hydrogen L-Tartrate Monohydrate; 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1); L-Noradrenaline Bitartrate Monohydrate; Norepinephrine (bitartrate monohydrate)
Molecular FormulaC12H19NO10
Molecular Weight337.28
Purity≥97 (LC/MS)%
Boiling Point442.6ºC at 760mmHg
Melting Point100-104ºC(lit.)
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 108341-18-0 |
| Catalog No. | 2A-9050396 |
| Chinese Name | 重酒石酸去甲肾上腺素 |
| Synonyms | Norepinephrine Bitartrate; L-Arterenol Bitartrate Monohydrate; (2R,3R)-2,3-Dihydroxysuccinic acid - 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol (1:1); MFCD00150449; 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1); L-(-)-Norepinephrine (+)-bitartrate salt monohydrate; 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1); L-Norepinephrine Bitartrate Monohydrate; Noradrenaline bitartrate monohydrate; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt); L-Norepinephrine Hydrogen L-Tartrate Monohydrate; 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1); L-Noradrenaline Bitartrate Monohydrate; Norepinephrine (bitartrate monohydrate) |
| Molecular Formula | C12H19NO10 |
| Molecular Weight | 337.28 |
| Purity | ≥97 (LC/MS) |
| Boiling Point | 442.6ºC at 760mmHg |
| Melting Point | 100-104ºC(lit.) |
| Appearance | crystalline solid |
| Water Solubility | H2O: soluble50mg/mL, clear |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Packaging | III |
| Application | Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with an EC50 of 5.37 μM. |
| HTC | 2922210000 |
| MDL Number | MFCD00150449 |
| SMILES | NC[C@H](O)c1cc(c(cc1)O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O |
| InChI | 1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1 |
| InChI Key | LNBCGLZYLJMGKP-LUDZCAPTSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/50396_1_108341_18_0.pdf |
| Bioactivity | Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease Target EC50: 5.37 μM (β1-selective adrenergic receptor)[1] In Vitro Norepinephrine(NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. Cell Assay Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2]. References [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. Chemical & Physical Properties Boiling Point 442.6ºC at 760mmHg Melting Point 100-104ºC(lit.) Molecular Formula C12H19NO10 Molecular Weight 337.28 Flash Point 221.5ºC PSA 201.77000 Vapour Pressure 1.3E-08mmHg at 25°C Index of Refraction -11 ° (C=5, H2O) InChIKey LNBCGLZYLJMGKP-CDHMMBEJSA-N SMILES NCC(O)c1ccc(O)c(O)c1.O.O=C(O)C(O)C(O)C(=O)O Storage condition Refrigerator Water Solubility H2O: soluble50mg/mL, clear |
| Use of | Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Properties Name l-noradrenaline bitartrate Synonym More Synonyms Norepinephrine Bitartrate Biological Activity Description Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease EC50: 5.37 μM (β1-selective adrenergic receptor)[1] In Vitro Norepinephrine(NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. References [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. Chemical & Physical Properties Molecular Formula C12H19NO10 PSA 201.77000 InChIKey LNBCGLZYLJMGKP-CDHMMBEJSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III |
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