CAS Number107761-42-2
Synonymsβ-amyloid 42; Amyloid Beta-Peptide (1-42) (human); beta-Amyloid (1-42) human; β-amyloid polypeptide 42; β-amyloid protein 42; MFCD01864012; Human β-amyloid peptide (1-42); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Bate-Amyloid （ 1-42 ） human; Amyloid β-Peptide (1-42) (human)
Molecular FormulaC203H311N55O60S
Molecular Weight4514.04
Purity≥95 (HPLC)%
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 107761-42-2 |
| Catalog No. | 2A-9050365 |
| Chinese Name | β-淀粉样多肽 |
| Synonyms | β-amyloid 42; Amyloid Beta-Peptide (1-42) (human); beta-Amyloid (1-42) human; β-amyloid polypeptide 42; β-amyloid protein 42; MFCD01864012; Human β-amyloid peptide (1-42); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Bate-Amyloid （ 1-42 ） human; Amyloid β-Peptide (1-42) (human) |
| Molecular Formula | C203H311N55O60S |
| Molecular Weight | 4514.04 |
| Purity | ≥95 (HPLC) |
| Appearance | powder |
| Storage Condition | Store airtight in a cool, dry warehouse. Refrigera |
| Application | Amyloid β-Peptide (1-42) human is a 42-amino acid peptide that plays a key role in the pathogenesis of Alzheimer's disease. |
| HTC | 29332900 |
| MDL Number | MFCD00163049 |
| SMILES | S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC( |
| InChI | 1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112 |
| InChI Key | DZHSAHHDTRWUTF-SIQRNXPUSA-N |
| NACRES Code | NA.32 |
| UNSPSC | 12352202 |
| Hazard Symbols | transportation |
| MSDS | msds/50365_1_107761_42_2.pdf |
| Bioactivity | Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease In Vitro Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2]. Cell Assay SH-SY5Y cells are treated with biotinylated Amyloid β-Peptide (1-42) human peptide 1 μM. Cells are fixed and permeabilized with 3.3% formaldehyde containing 0.5% Triton X-100 followed by 125 mM glycine in PBS containing magnesium and calcium. Cells are blocked with 5% fetal bovine calf serum followed by the primary antibody. Biotin-Amyloid β-Peptide (1-42) human peptide is detected with the monoclonal antibody AB or alternatively with Avidin Fluor488. Nuclei are stained with DAPI. Images are obtained using an LSM 510 meta confocal microscope[2]. Chemical & Physical Properties Molecular Formula C203H311N55O60S Molecular Weight 4514.04000 Exact Mass 4511.27000 PSA 1840.49000 LogP 1.35150 Storage condition −20°C |
| Use of | Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Properties Name Amyloid|A-Peptide (1-42) (human) Synonym More Synonyms β-Amyloid-42 Biological Activity Description Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease Chemical & Physical Properties Molecular Formula C203H311N55O60S Exact Mass 4511.27000 PSA 1840.49000 LogP 1.35150 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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