CAS Number106308-44-5
Synonyms1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide; 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; Rufinamide; 1-((2,6-Difluorophenyl)methyl)-1H-1,2,3-triazole-4-carboxamide; Banzel; Inovelon
Molecular FormulaC10H8F2N4O
Molecular Weight238.19
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point473.8±55.0 °C at 760 mmHg
Melting Point232-234?C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 106308-44-5 |
| Catalog No. | 2A-9050263 |
| Chinese Name | 卢非酰胺 |
| Synonyms | 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide; 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; Rufinamide; 1-((2,6-Difluorophenyl)methyl)-1H-1,2,3-triazole-4-carboxamide; Banzel; Inovelon |
| Molecular Formula | C10H8F2N4O |
| Molecular Weight | 238.19 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 473.8±55.0 °C at 760 mmHg |
| Melting Point | 232-234?C |
| Appearance | powder |
| Water Solubility | DMSO: soluble9mg/mL |
| Storage Condition | −20°C |
| Application | Rufinamide (E 2080; CGP 33101; RUF 331) is a new antiepileptic compound that can be used as an adjuvant treatment for Lennox-Gastaut syndrome. |
| PubChem ID | 24724595 |
| MDL Number | MFCD00865314 |
| SMILES | NC(=O)c1cn(Cc2c(F)cccc2F)nn1 |
| InChI | 1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) |
| InChI Key | POGQSBRIGCQNEG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/50263_1_106308_44_5.pdf |
| Bioactivity | Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2 Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 473.8±55.0 °C at 760 mmHg Melting Point 232-234?C Molecular Formula C10H8F2N4O Molecular Weight 238.193 Flash Point 240.4±31.5 °C Exact Mass 238.066620 PSA 73.80000 LogP 0.05 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.635 InChIKey POGQSBRIGCQNEG-UHFFFAOYSA-N SMILES NC(=O)c1cn(Cc2c(F)cccc2F)nn1 Storage condition −20°C Water Solubility DMSO: soluble9mg/mL |
| Use of | Properties Articles39 Name Rufinamide Synonym More Synonyms Rufinamide Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20. Chemical & Physical Properties Molecular Formula C10H8F2N4O Exact Mass 238.066620 PSA 73.80000 Index of Refraction 1.635 InChIKey POGQSBRIGCQNEG-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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