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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > N-Boc-cis-4-Hydroxy-L-proline methyl ester
N-Boc-cis-4-Hydroxy-L-proline methyl ester structure, CAS 102195-79-9

N-Boc-cis-4-Hydroxy-L-proline methyl ester

CAS Number102195-79-9

Synonyms(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester; N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester; 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; N-Boc-cis-4-Hydroxy-L-prolinem ethylester; (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate; MFCD00237541; N-Boc-cis-4-hydroxy-L-proline methyl ester; 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate; Boc-cis-Hyp-OMe; cis-Boc-Hyp-OMe

Molecular FormulaC11H19NO5

Molecular Weight245.27

Purity97%

Density1.2±0.1 g/cm3

Boiling Point335.2±42.0 °C at 760 mmHg

Melting Point82-86 °C (lit.)

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9049895 Purity: 97%
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Quality Control of [ 102195-79-9 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number102195-79-9
Catalog No.2A-9049895
Chinese NameBoc-顺式-4-羟基-L-脯氨酸甲酯
Synonyms(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester; N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester; 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; N-Boc-cis-4-Hydroxy-L-prolinem ethylester; (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate; MFCD00237541; N-Boc-cis-4-hydroxy-L-proline methyl ester; 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate; Boc-cis-Hyp-OMe; cis-Boc-Hyp-OMe
Molecular FormulaC11H19NO5
Molecular Weight245.27
Purity97
Density1.2±0.1 g/cm3
Boiling Point335.2±42.0 °C at 760 mmHg
Melting Point82-86 °C (lit.)
Appearancesolid
Storage ConditionStore airtight in a cool, dry warehouse. Keep away
ApplicationN-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also an alkyl chain-based P
HTC2933990090
PubChem ID24884007
MDL NumberMFCD00237541
SMILESCOC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C
InChI1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8-/m0/s1
InChI KeyMZMNEDXVUJLQAF-YUMQZZPRSA-N
NACRES CodeNA.22
UNSPSC12352209
Hazard Symbolstransportation
MSDSmsds/49895_1_102195_79_9.pdf
BioactivityN-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 335.2±42.0 °C at 760 mmHg Melting Point 82-86ºC Molecular Formula C11H19NO5 Molecular Weight 245.272 Flash Point 156.6±27.9 °C Exact Mass 245.126328 PSA 76.07000 LogP -0.25 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.501 InChIKey MZMNEDXVUJLQAF-YUMQZZPRSA-N SMILES COC(=O)C1CC(O)CN1C(=O)OC(C)(C)C Storage condition -15°C
Use ofN-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Properties Name N-Boc-cis-4-hydroxy-L-proline Methyl Ester Synonym More Synonyms Biological Activity Description N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C11H19NO5 Exact Mass 245.126328 PSA 76.07000 LogP -0.25 Index of Refraction 1.501 InChIKey MZMNEDXVUJLQAF-YUMQZZPRSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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