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Finasteride structure, CAS 98319-26-7

Finasteride

CAS Number98319-26-7

SynonymsProscar; Finasteride; Prostide; Finasterida; 17b-(N-tert-Butylcarbamoyl)-4-aza-5a-androst-1-en-3-one; (5a,17b)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; MK-906; Chibro-Proscar; Finastid; Propecia; Finpecia; Propecia (TN); Proscar (TN); MFCD00869737; Finasteridum

Molecular FormulaC23H36N2O2

Molecular Weight372.54

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point576.6±50.0 °C at 760 mmHg

Melting Point253 °C

Flash Point

AppearanceWhite to off-white crystalline powder

EINECS

MSDSChineseEnglish

SymbolT

Signal WordWarning

Cat. No.: 2A-9049494 Purity: 98.00%
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Quality Control of [ 98319-26-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number98319-26-7
Catalog No.2A-9049494
Chinese Name非那雄胺
SynonymsProscar; Finasteride; Prostide; Finasterida; 17b-(N-tert-Butylcarbamoyl)-4-aza-5a-androst-1-en-3-one; (5a,17b)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; MK-906; Chibro-Proscar; Finastid; Propecia; Finpecia; Propecia (TN); Proscar (TN); MFCD00869737; Finasteridum
Molecular FormulaC23H36N2O2
Molecular Weight372.54
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point576.6±50.0 °C at 760 mmHg
Melting Point253 °C
AppearanceWhite to off-white crystalline powder
Water Solubilityinsoluble
Storage ConditionStore airtight in a cool, dry warehouse.
ApplicationFinasteride is an orally active testosterone 5α-reductase inhibitor with a Ki of 10 nM.
HTC2937290090
PubChem ID7847387
SMILESCC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C
InChIInChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChI KeyDBEPLOCGEIEOCV-WSBQPABSSA-N
Hazard SymbolsT
Risk CodesR22;R60;R61
Safety DescriptionS36/37/39;S45;S53
BioactivityFinasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM). Target: 5-alpha ReductaseApproved: 1992Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10 nM, significantly lower than in stroma (Ki = 33nM) [1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> 5 alpha Reductase Research Areas >> Cancer References [1]. Weisser, H. and M. Krieg, In vitro inhibition of androstenedione 5alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol, 1998. 67(1): p. 49-55. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 576.6±50.0 °C at 760 mmHg Melting Point 253 °C Molecular Formula C23H36N2O2 Molecular Weight 372.544 Flash Point 177.4±30.3 °C Exact Mass 372.277679 PSA 58.20000 LogP 3.24 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.524 InChIKey DBEPLOCGEIEOCV-WSBQPABSSA-N SMILES CC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C Storage condition Store at RT Water Solubility insoluble
Use ofFinasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM). Target: 5-alpha ReductaseApproved: 1992Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10 nM, significantly lower than in stroma (Ki = 33nM) [1]. Properties Articles106 Name finasteride Synonym More Synonyms Finasteride Biological Activity Description Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM). Target: 5-alpha ReductaseApproved: 1992Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10 nM, significantly lower than in stroma (Ki = 33nM) [1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> 5 alpha Reductase Research Areas >> Cancer References [1]. Weisser, H. and M. Krieg, In vitro inhibition of androstenedione 5alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol, 1998. 67(1): p. 49-55. Chemical & Physical Properties Molecular Formula C23H36N2O2 Exact Mass 372.277679 PSA 58.20000 Index of Refraction 1.524 InChIKey DBEPLOCGEIEOCV-WSBQPABSSA-N Storage condition Store at RT Water Solubility insoluble
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Finasteride Modification Number: 5
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