CAS Number85650-56-2
Synonymstrans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate; Asenapine maleate; Asenapine; Saphris; Asenapine (maleate); trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oxepino[4,5-C]pyrrolidino maleate; Sycrest; trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate; trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate
Molecular FormulaC21H20ClNO5
Molecular Weight401.84000
Purity98.00%
Boiling Point357.9ºC at 760 mmHg
Melting Point141-145°
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85650-56-2 |
| Catalog No. | 2A-9049270 |
| Chinese Name | 阿塞那平马来酸盐 |
| Synonyms | trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate; Asenapine maleate; Asenapine; Saphris; Asenapine (maleate); trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oxepino[4,5-C]pyrrolidino maleate; Sycrest; trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate; trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate |
| Molecular Formula | C21H20ClNO5 |
| Molecular Weight | 401.84000 |
| Purity | 98.00 |
| Boiling Point | 357.9ºC at 760 mmHg |
| Melting Point | 141-145° |
| Water Solubility | H2O: ≥10mg/mL |
| Storage Condition | 2-8°C |
| Application | Asenapine maleate is an antagonist of 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2, with Ki values of 0.03-4.0 nM and 1.3 nM respectively. It is also an antipsychotic drug. |
| HTC | 29339900 |
| PubChem ID | 12013479 |
| SMILES | CN1C[C@@H]2[C@@H](C1)c3cc(Cl)ccc3Oc4ccccc24.OC(=O)\C=C/C(O)=O |
| InChI | InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m0./s1 |
| InChI Key | InChIKey=GMDCDXMAFMEDAG-TXUHOWFZSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/49270_1_85650_56_2.pdf |
| Bioactivity | Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease Target 5-HT1A Receptor:2.5 nM (Ki) 5-HT2A Receptor:0.06 nM (Ki) 5-HT2C Receptor:0.03 nM (Ki) 5-HT7 Receptor:0.13 nM (Ki) D2 Receptor:1.3 nM (Ki) D3 Receptor:0.42 nM (Ki) D4 Receptor:1.1 nM (Ki) In Vitro Relative to its D2 receptor affinity, asenapine has a higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8) and H1 (8.4) receptors[2]. In Vivo Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats[3]. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice[4]. Animal Admin Rats: Asenapine maleate is suspended in 10% hydroxypropyl-β-cyclodextrin and administered in a volume of 1 mL/kg body weight . Rats are individually fear conditioned using electrical foot shock in a Skinner box. Animals are injected intraperitoneally (i.p.) with asenapine, clozapine, olanzapine, buspirone, or SB242084 at 30 min before freezing behaviour assessment[3]. Mice: Male ICR mice are repeatedly treated with 0.1 or 0.3mg/kg injections of asenapine and then tested in a battery of behavioural tests related to anxiety including the open-field test, elevated plus-maze (EPM), defensive marble burying and hyponeophagia tests[4]. References [1]. Stoner SC, et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [3]. Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. [4]. Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91. Chemical & Physical Properties Boiling Point 357.9ºC at 760 mmHg Melting Point 141-145° Molecular Formula C21H20ClNO5 Molecular Weight 401.84000 Flash Point 170.2ºC Exact Mass 401.10300 PSA 87.07000 LogP 3.90820 Storage condition 2-8°C Water Solubility H2O: ≥10mg/mL |
| Use of | Properties Name Asenapine maleate Synonym More Synonyms Asenapine Maleate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease 5-HT1A Receptor:2.5 nM (Ki) 5-HT2A Receptor:0.06 nM (Ki) 5-HT7 Receptor:0.13 nM (Ki) D2 Receptor:1.3 nM (Ki) D3 Receptor:0.42 nM (Ki) D4 Receptor:1.1 nM (Ki) In Vivo Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats[3]. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice[4]. References [1]. Stoner SC, et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [3]. Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. [4]. Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91. Chemical & Physical Properties Exact Mass 401.10300 PSA 87.07000 LogP 3.90820 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. (trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate) International air transport hazard regulations: Toxic solid, organic, n.o.s. (trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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