CAS Number85416-75-7
Synonyms(-)-rolipram; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (R)-(-)-Rolipram; R-(-)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; (S)-ROLIPRAM
Molecular FormulaC16H21O3N1
Molecular Weight275.35
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point472.7±45.0 °C at 760 mmHg
Melting Point134 °C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85416-75-7 |
| Catalog No. | 2A-9049237 |
| Chinese Name | (−)-Rolipram |
| Synonyms | (-)-rolipram; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (R)-(-)-Rolipram; R-(-)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; (S)-ROLIPRAM |
| Molecular Formula | C16H21O3N1 |
| Molecular Weight | 275.35 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 472.7±45.0 °C at 760 mmHg |
| Melting Point | 134 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | <0°C; avoid heating |
| Application | (R)-(-)-Rolipram is a cAMP-specific PDE4 inhibitor with an IC50 of 220nM. In the experiment of inhibiting PDE4 membrane binding, its inhibitory effect is 2.5 times higher than (+)-rolipram. |
| HTC | 2933790090 |
| PubChem ID | 7885372 |
| MDL Number | MFCD03093860 |
| SMILES | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 |
| InChI | InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) |
| InChI Key | HJORMJIFDVBMOB-LBPRGKRZSA-N |
| MSDS | msds/49237_1_85416_75_7.pdf |
| Use of | (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Properties Name (4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one Synonym More Synonyms (R)-(-)-Rolipram Biological Activity Description (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease References [1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944. Chemical & Physical Properties Molecular Formula C16H21NO3 Exact Mass 275.152130 PSA 47.56000 Index of Refraction 1.552 InChIKey HJORMJIFDVBMOB-LBPRGKRZSA-N Safety Information HS Code 2933790090 Synthetic Route 479258-11-2 (R)-(-)-Rolipra... 85416-75-7 Literature: Itoh, Kennosuke; Kanemasa, Shuji Journal of the American Chemical Society, 2002 , vol. 124, # 45 p. 13394 - 13395 3-(Cyclopentylo... 67387-76-2 (R)-(-)-Rolipra... 85416-75-7 Literature: Wu, Baogen; Kuhen, Kelli; Ngoc Nguyen, Truc; Ellis, David; Anaclerio, Beth; He, Xiaohui; Yang, Kunyong; Karanewsky, Donald; Yin, Hong; Wolff, Karen; Bieza, Kimberly; Caldwell, Jeremy; He, Yun Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3430 - 3433 Isovanillin (R)-(-)-Rolipra... 85416-75-7 Literature: Itoh, Kennosuke; Kanemasa, Shuji Journal of the American Chemical Society, 2002 , vol. 124, # 45 p. 13394 - 13395 Precursor & DownStream Precursor 5 CAS#:67387-76-2 3-(Cyclopentylo... CAS#:621-59-0 Isovanillin CAS#:1021867-92-4 methyl 3-(3-cyc... CAS#:137-43-9 Bromocyclopentane DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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