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Rilmenidine phosphate structure, CAS 85409-38-7

Rilmenidine phosphate

CAS Number85409-38-7

Synonyms2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1); N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine phosphate (1:1); Rilmenidine phosphate; 2-Oxazolamine, 4,5-dihydro-N-(dicyclopropylmethyl)-, phosphate (1:1); S 3341-3 {Phosphate}; Rilmenidine dihydrogen phosphate; S 3341-3; EINECS 287-106-2; 4,5-Dihydro-N-(dicyclopropylmethyl)-2-oxazolamine phosphate (1:1); Hyperium

Molecular FormulaC10H19N2O5P

Molecular Weight278.24

Purity98.00%

Density

Boiling Point609.1ºC at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9049235 Purity: 98.00%
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Quality Control of [ 85409-38-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number85409-38-7
Catalog No.2A-9049235
Chinese Name磷酸利美尼定
Synonyms2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1); N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine phosphate (1:1); Rilmenidine phosphate; 2-Oxazolamine, 4,5-dihydro-N-(dicyclopropylmethyl)-, phosphate (1:1); S 3341-3 {Phosphate}; Rilmenidine dihydrogen phosphate; S 3341-3; EINECS 287-106-2; 4,5-Dihydro-N-(dicyclopropylmethyl)-2-oxazolamine phosphate (1:1); Hyperium
Molecular FormulaC10H19N2O5P
Molecular Weight278.24
Purity98.00
Boiling Point609.1ºC at 760 mmHg
Appearancepowder
Water SolubilityFreely soluble in water, slightly soluble in alcoh
Storage Condition-20℃
ApplicationRilmenidine phosphate is a novel antihypertensive drug and orally active selective I1 imidazoline receptor agonist. Rilmenidine phosphate exerts central effects by reducing sympathetic overactivity an
HTC2934999090
PubChem ID10262929
SMILES[P](=O)([O-])(O)O.[N+H2](C(C3CC3)C2CC2)C1=NCCO1
InChI1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4)
InChI KeyZJCOWRFWZOAVFY-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/49235_1_85409_38_7.pdf
Use ofProperties Name N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric acid Synonym More Synonyms Rilmenidine phosphate Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor In Vivo Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[4]. Rilmenidine phosphate decreases levels of mutant huntingtin[4]. References [1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [3]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [4]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. Chemical & Physical Properties Molecular Formula C10H19N2O5P Exact Mass 278.103149 PSA 121.19000 LogP 0.04870 InChIKey ZJCOWRFWZOAVFY-UHFFFAOYSA-N Storage condition -20℃ Water Solubility Freely soluble in water, slightly soluble in alcohol, practically insoluble in methylene chloride. Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : 85409-38-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H16-N2-O.H3-O4-P MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 8,56,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 8,56,1990 Safety Information HS Code 2934999090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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