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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82508-31-4 |
| Catalog No. | 2A-9048753 |
| Chinese Name | 土槿皮乙酸； 土荆皮乙酸 |
| Synonyms | PLAB; PseudolaricAcidB; Pseudolarix acid B |
| Molecular Formula | C23H28O8 |
| Molecular Weight | 432.46 |
| Purity | ≥98.0 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 613.8±55.0 °C at 760 mmHg |
| Melting Point | 166°C |
| Appearance | solid |
| Water Solubility | methanol: soluble1mg/mL, clear, colorless |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Pseudolaric Acid B is a diterpene acid isolated from the roots of Pseudolarix kaempferi Gorden (pinaceae) with anticancer, antifungal, antifertilization activity, and immunosuppressive activity agains |
| PubChem ID | 644173 |
| MDL Number | MFCD26960905 |
| SMILES | O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1 |
| InChI | 1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1 |
| InChI Key | XRLYZNSOXNPKOR-CBDALDGHSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/48753_1_82508_31_4.pdf |
| Bioactivity | Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology References [1]. Zhou BN, et al. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26. [2]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90. [3]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. [4]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525. [5]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 613.8±55.0 °C at 760 mmHg Melting Point 166°C Molecular Formula C23H28O8 Molecular Weight 432.464 Flash Point 208.8±25.0 °C Exact Mass 432.178406 PSA 116.20000 LogP 2.78 Appearance of Characters white to off-white Vapour Pressure 0.0±3.8 mmHg at 25°C Index of Refraction 1.565 InChIKey VDGOFNMYZYBUDT-BBFYDTLNSA-N SMILES COC(=O)C1=CCC23CCC(C(C)(C=CC=C(C)C(=O)O)OC2=O)C3(OC(C)=O)CC1 Storage condition 2-8°C Water Solubility methanol: soluble1mg/mL, clear, colorless |
| Use of | Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5]. Properties Articles22 Name pseudolaric acid b Synonym More Synonyms Pseudolaric acid B Biological Activity Description Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology References [1]. Zhou BN, et al. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26. [2]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90. [3]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. [4]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525. [5]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737. Chemical & Physical Properties Molecular Formula C23H28O8 Exact Mass 432.178406 PSA 116.20000 Appearance of Characters white to off-white Index of Refraction 1.565 InChIKey VDGOFNMYZYBUDT-BBFYDTLNSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Pseudolaric acid B) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Pseudolaric acid B) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Pseudolaric acid B) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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