CAS Number82436-77-9
SynonymsBis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS)); BS(3) Cpd; MFCD00054982; 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis(2,5-dioxo-3-pyrrolidinesulfonic acid); Bis(sulfosuccinimidyl) suberate sodium salt; BSSIS; bis(sulfosuccinimidyl)suberate; Disulfosuccinimidyl suberate
Molecular FormulaC16H20N2O14S2
Molecular Weight572.43
Purity≥95 (H-NMR)%
Melting Point>300°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82436-77-9 |
| Catalog No. | 2A-9048744 |
| Chinese Name | 双琥珀酰亚胺辛二酸酯钠盐 |
| Synonyms | Bis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS)); BS(3) Cpd; MFCD00054982; 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis(2,5-dioxo-3-pyrrolidinesulfonic acid); Bis(sulfosuccinimidyl) suberate sodium salt; BSSIS; bis(sulfosuccinimidyl)suberate; Disulfosuccinimidyl suberate |
| Molecular Formula | C16H20N2O14S2 |
| Molecular Weight | 572.43 |
| Purity | ≥95 (H-NMR) |
| Melting Point | >300°C |
| Appearance | powder |
| Water Solubility | H2O: 10 mg/mL |
| Storage Condition | Refrigerated and airtight at -20°C |
| Application | BS3 Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADC). |
| PubChem ID | 329824554 |
| MDL Number | MFCD00054982 |
| SMILES | [Na+].[Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)CCCCCCC(=O)ON2C(=O)CC(C2=O)S([O-])(=O)=O)C1=O |
| InChI | 1S/C16H20N2O14S2.2Na/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30;;/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30);;/q;2*+1/p-2 |
| InChI Key | MGJYOHMBGJPESL-UHFFFAOYSA-L |
| NACRES Code | NA.22 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/48744_1_82436_77_9.pdf |
| Bioactivity | BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Chemical & Physical Properties Melting Point >300°C Molecular Formula C16H20N2O14S2 Molecular Weight 550.447 Exact Mass 550.017517 PSA 255.69000 Appearance of Characters powder InChIKey VYLDEYYOISNGST-UHFFFAOYSA-N SMILES O=C(CCCCCCC(=O)ON1C(=O)CC(S(=O)(=O)O)C1=O)ON1C(=O)CC(S(=O)(=O)O)C1=O Storage condition −20°C Water Solubility H2O: 10 mg/mL |
| Use of | Properties Articles188 Name 1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Synonym More Synonyms Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Chemical & Physical Properties Molecular Formula C16H20N2O14S2 Exact Mass 550.017517 PSA 255.69000 Appearance of Characters powder InChIKey VYLDEYYOISNGST-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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