CAS Number81267-65-4
Synonyms7-hydroxy-3-(4-hydroxy-phenyl)-2H-1-benzopyran; Haginin E; 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; IDRONOXIL; Phenoxodiol; Dehydroequol; 3-(4-Hydroxyphenyl)-2H-chromen-7-ol; NV-06; 4',7-dihydroxyisoflav-3-ene; 4',7-dihydroxy-3-phenyl-3,4-dehydrochroman
Molecular FormulaC15H12O3
Molecular Weight240.25
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point463.7±45.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 81267-65-4 |
| Catalog No. | 2A-9048597 |
| Chinese Name | 脱氢雌马酚 |
| Synonyms | 7-hydroxy-3-(4-hydroxy-phenyl)-2H-1-benzopyran; Haginin E; 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; IDRONOXIL; Phenoxodiol; Dehydroequol; 3-(4-Hydroxyphenyl)-2H-chromen-7-ol; NV-06; 4',7-dihydroxyisoflav-3-ene; 4',7-dihydroxy-3-phenyl-3,4-dehydrochroman |
| Molecular Formula | C15H12O3 |
| Molecular Weight | 240.25 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 463.7±45.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C, dry, sealed |
| Application | Phenoxodiol is a synthetic genestein analog that activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes cancer cells to fas-mediated apoptosis. Phenoxodiol |
| HTC | 2932999099 |
| PubChem ID | 3191506 |
| MDL Number | MFCD06636630 |
| SMILES | Oc1ccc(C2=Cc3ccc(O)cc3OC2)cc1 |
| InChI | InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2 |
| InChI Key | ZZUBHVMHNVYXRR-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| MSDS | msds/48597_1_81267_65_4.pdf |
| Bioactivity | Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Apoptosis >> Caspase Target Caspase, DNA topoisomerase II[1][2]. References [1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 463.7±45.0 °C at 760 mmHg Molecular Formula C15H12O3 Molecular Weight 240.254 Flash Point 234.3±28.7 °C Exact Mass 240.078644 PSA 49.69000 LogP 4.35 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.679 InChIKey ZZUBHVMHNVYXRR-UHFFFAOYSA-N SMILES Oc1ccc(C2=Cc3ccc(O)cc3OC2)cc1 |
| Use of | Properties Name 3-(4-hydroxyphenyl)-2H-chromen-7-ol Synonym More Synonyms Phenoxodiol Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Apoptosis >> Caspase Caspase, DNA topoisomerase II[1][2]. References [1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110. Chemical & Physical Properties Molecular Formula C15H12O3 Exact Mass 240.078644 PSA 49.69000 Index of Refraction 1.679 InChIKey ZZUBHVMHNVYXRR-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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