![Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']manganese structure, CAS 81065-76-1](/structures/60000/48568_1_81065_76_1.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 81065-76-1 |
| Catalog No. | 2A-9048568 |
| Chinese Name | 乙基双亚氨基甲基愈创木酚锰氯化物 |
| Synonyms | ethylbisiminomethylguaiacol manganese chloride; I14-7464; EUK-134 |
| Molecular Formula | C18H18ClMnN2O4 |
| Molecular Weight | 416.74 |
| Purity | ≥95 (HPLC) |
| Appearance | powder |
| Water Solubility | H2O: soluble2mg/mL, clear (warmed) |
| Storage Condition | ?20°C |
| Application | EUK-134 is a synthetic superoxide dismutase and catalase mimetic that protects rat kidneys from ischemia-reperfusion injury. EUK-134 is a superoxide dismutase (SOD) mimetic (SODm) with catalase activi |
| PubChem ID | 14782285 |
| SMILES | [Mn+2]Cl.N(=Cc2c(c(ccc2)OC)[O-])CCN=Cc1c(c(ccc1)OC)[O-] |
| InChI | 1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3 |
| InChI Key | YUZJJFWCXJDFOQ-UHFFFAOYSA-K |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/48568_1_81065_76_1.pdf |
| Bioactivity | EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Target NF-κB In Vitro EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2]. Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2]. EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3]. Cell Viability Assay[2] Cell Line: NRK-52E cells Concentration: 0, 1, 3, 10, 30, 100, and 300 μM Incubation Time: 24 hours Result: Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM. References [1]. P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6. [2]. Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34. [3]. Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94. Chemical & Physical Properties Molecular Formula C18H18ClMnN2O4 Molecular Weight 416.738 Exact Mass 416.033569 PSA 58.62000 LogP 3.09010 Appearance of Characters , faint to very dark brown InChIKey YUZJJFWCXJDFOQ-UHFFFAOYSA-K SMILES COc1cccc(C=NCCN=Cc2cccc(OC)c2[O-])c1[O-].[Cl-].[Mn+3] Storage condition ?20°C Water Solubility H2O: soluble2mg/mL, clear (warmed) |
| Use of | Properties Name manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride Synonym More Synonyms EUK-134 Biological Activity Related Catalog Research Areas >> Cardiovascular Disease References [1]. P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6. [2]. Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34. Chemical & Physical Properties Exact Mass 416.033569 PSA 58.62000 LogP 3.09010 Appearance of Characters , faint to very dark brown InChIKey YUZJJFWCXJDFOQ-UHFFFAOYSA-K |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 6-Ethylthio-3-hepten-2-one | 81008-52-8 | 2A-9048555 |
| 1-Naphthyl phosphate monosodium salt monohydrate | 81012-89-7 | 2A-9048558 |
| 3-Hydroxybenzylhydrazine dihydrochloride | 81012-99-9 | 2A-9048561 |
| 2,3-Dimethyl-4-nitroanisole | 81029-03-0 | 2A-9048563 |
| Brilliant Cresyl Blue | 81029-05-2 | 2A-9048564 |
| 5-(Dimethylaminomethyl)furfuryl alcohol hydrochloride | 81074-81-9 | 2A-9048570 |
| 2,3-Dimethylbenzyl bromide | 81093-21-2 | 2A-9048572 |
| D-2-Methylbutyl 2-methylbutyrate | 81115-67-5 | 2A-9048578 |
| Gastrin I Rat | 81123-06-0 | 2A-9048579 |
| 2-Methyl-D-serine | 81132-44-7 | 2A-9048582 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS