CAS Number78842-13-4
Synonyms2'-fluorodeoxyguanisine; 2'-Fluoro-2'-deoxyguanosine; 2'-fluorodeoxyguanosine; 2'-fluoro guanosine; 2'-fluoro-2',3'-dideoxyguanosine; 2'-Dfgs; 2'-Deoxy-2'-fluoroguanosine; Guanosine,2'-deoxy-2'-fluoro
Molecular FormulaC10H12O4N5F1
Molecular Weight285.23
Purity98.00%
Density2.2±0.1 g/cm3
AppearancePowder | White to Off-white
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78842-13-4 |
| Catalog No. | 2A-9048281 |
| Chinese Name | 2'-氟-2'-脱氧鸟苷 |
| Synonyms | 2'-fluorodeoxyguanisine; 2'-Fluoro-2'-deoxyguanosine; 2'-fluorodeoxyguanosine; 2'-fluoro guanosine; 2'-fluoro-2',3'-dideoxyguanosine; 2'-Dfgs; 2'-Deoxy-2'-fluoroguanosine; Guanosine,2'-deoxy-2'-fluoro |
| Molecular Formula | C10H12O4N5F1 |
| Molecular Weight | 285.23 |
| Purity | 98.00 |
| Density | 2.2±0.1 g/cm3 |
| Appearance | Powder | White to Off-white |
| Storage Condition | room temperature |
| Application | 2′-Deoxy-2′-fluoroguanosine, a nucleoside analogue, is a potent inhibitor of influenza virus, with an EC90 value of <0.35 μM for influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine can significantl |
| HTC | 2934999090 |
| PubChem ID | 3718034 |
| MDL Number | MFCD00923832 |
| SMILES | NC1=NC(=O)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3F)c2N1 |
| InChI | InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1 |
| InChI Key | InChIKey=UXUZARPLRQRNNX-DXTOWSMRSA-N |
| MSDS | msds/48281_1_78842_13_4.pdf |
| Use of | 2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2]. Properties Name 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one Synonym More Synonyms 2′-Deoxy-2′-fluoroguanosine Biological Activity Description 2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection EC90: <0.35 μM (influenza virus A and B)[1] References [1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8. [2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7. Chemical & Physical Properties Molecular Formula C10H12FN5O4 Exact Mass 285.087341 PSA 140.27000 LogP -0.53 Appearance of Characters Powder | White to Off-white Index of Refraction 1.876 Safety Information Hazard Codes Xn HS Code 2934999090 Synthetic Route N2-ibu-2'-F... 80681-25-0 2′-Deoxy-... 78842-13-4 Literature: Kawasaki; Casper; Freier; Lesnik; Zounes; Cummins; Gonzalez; Cook Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 831 - 841 75173-96-5 2′-Deoxy-... 78842-13-4 146954-68-9 2′-Deoxy-... 78842-13-4 Literature: Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647 Precursor & DownStream Precursor 5 CAS#:80681-25-0 N2-ibu-2'-F-dG CAS#:129835-17-2 9-(3',5'-O-(1,1... CAS#:134444-47-6 2-Amino-2'-deox... CAS#:149623-91-6 1-O-acetyl-3,5-... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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