| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78613-38-4 |
| Catalog No. | 2A-9048254 |
| Chinese Name | 盐酸阿莫洛芬 |
| Synonyms | Loceryl; Locetar; Amorolfine Hydrochloride; MFCD00903738; Curanail; Amorolfine HCl; Odenil |
| Molecular Formula | C21H36O1N1Cl1 |
| Molecular Weight | 353.98 |
| Purity | 98.00 |
| Density | 1.234 |
| Boiling Point | 78-82°C (9 Torr) |
| Appearance | white powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | room temp |
| Application | Amorolfine hydrochloride is an antifungal agent. |
| HTC | 29411010 |
| PubChem ID | 7848783 |
| MDL Number | MFCD00903738 |
| SMILES | CCC(C)(C)c1ccc(CC(C)CN2CC(C)OC(C)C2)cc1.Cl |
| InChI | InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+; |
| InChI Key | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/48254_1_78613_38_4.pdf |
| Bioactivity | Amorolfine hydrochloride is a antifungal reagent.Target: AntifungalAmorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species [1]. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. Simultaneous addition of amorolfine resulted in a significant increase in killing at all concentrations. This increase was not significantly enhanced by either preincubation of neutrophils or blastospores for 2 h with the drug [2]. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection References [1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7. [2]. Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9. Chemical & Physical Properties Density 1.234 Boiling Point 78-82°C (9 Torr) Molecular Formula C21H36ClNO Molecular Weight 353.970 Exact Mass 353.248535 PSA 12.47000 LogP 5.40190 InChIKey XZKWIPVTHGWDCF-KUZYQSSXSA-N SMILES CCC(C)(C)c1ccc(CC(C)CN2CC(C)OC(C)C2)cc1.Cl Storage condition room temp |
| Use of | Properties Name amorolfine hydrochloride Synonym More Synonyms Amorolfine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection References [1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7. Chemical & Physical Properties Exact Mass 353.248535 PSA 12.47000 LogP 5.40190 InChIKey XZKWIPVTHGWDCF-KUZYQSSXSA-N Storage condition room temp |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Amorolfine hydrochloride) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Amorolfine hydrochloride) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Amorolfine hydrochloride) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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