CAS Number76547-98-3
SynonymsCARACE; 1-{N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl}-L-prolin; Lisinopril; Cipral; PRINIL; mk522; (2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid; Longes; (2S)-1-[(2S)-6-Amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]-2-pyrrolidinecarboxylic acid; MFCD00214086; N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-prolinato; Tensyn; N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline; Renacor; CORIC; mk0521; Linvas; EINECS 278-488-1; MK-521
Molecular FormulaC21H31N3O5
Molecular Weight405.49
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point666.4±55.0 °C at 760 mmHg
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76547-98-3 |
| Catalog No. | 2A-9048007 |
| Chinese Name | 赖诺普利 |
| Synonyms | CARACE; 1-{N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl}-L-prolin; Lisinopril; Cipral; PRINIL; mk522; (2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid; Longes; (2S)-1-[(2S)-6-Amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]-2-pyrrolidinecarboxylic acid; MFCD00214086; N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-prolinato; Tensyn; N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline; Renacor; CORIC; mk0521; Linvas; EINECS 278-488-1; MK-521 |
| Molecular Formula | C21H31N3O5 |
| Molecular Weight | 405.49 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 666.4±55.0 °C at 760 mmHg |
| Appearance | solid |
| Water Solubility | H2O: ≥10 mg/mL |
| Storage Condition | Store at 2-8 ºC. |
| Application | Lisinopril is an angiotensin-converting enzyme inhibitor that can act on hypertension, congestive heart failure and heart disease. |
| HTC | 2933990090 |
| PubChem ID | 7888691 |
| MDL Number | C21H31N3O5 |
| SMILES | NCCCCC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O |
| InChI | InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1 |
| InChI Key | RLAWWYSOJDYHDC-BZSNNMDCSA-N |
| MSDS | msds/48007_1_76547_98_3.pdf |
| Bioactivity | Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.Target: ACELisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy [1, 2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease Natural Products >> Alkaloid References [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54. [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 666.4±55.0 °C at 760 mmHg Molecular Formula C21H31N3O5 Molecular Weight 405.488 Flash Point 356.9±31.5 °C Exact Mass 405.226379 PSA 132.96000 LogP 1.19 Vapour Pressure 0.0±2.1 mmHg at 25°C Index of Refraction 1.578 InChIKey RLAWWYSOJDYHDC-BZSNNMDCSA-N SMILES NCCCCC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O Storage condition 2-8°C Water Solubility H2O: ≥10 mg/mL |
| Use of | Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.Target: ACELisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy [1, 2]. Properties Name lisinopril Synonym More Synonyms Lisinopril Biological Activity Description Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.Target: ACELisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy [1, 2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease Natural Products >> Alkaloid References [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54. [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. Chemical & Physical Properties Molecular Formula C21H31N3O5 Exact Mass 405.226379 PSA 132.96000 Index of Refraction 1.578 InChIKey RLAWWYSOJDYHDC-BZSNNMDCSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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