CAS Number75621-03-3
SynonymsCHAPS Solution; CHAPS ELECTROPHORESIS REAGENT; MFCD00012116; CHAPS-SOL GRADE; CHAPS; CHAPS extrapure; TREND
Molecular FormulaC32H58N2O7S
Molecular Weight614.88
Purity98.00%
Density1.01 g/mL at 20ºC
Melting Point156-158ºC
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 75621-03-3 |
| Catalog No. | 2A-9047889 |
| Chinese Name | 3-[(3-胆固醇氨丙基)二甲基氨基]-1-丙磺酸 |
| Synonyms | CHAPS Solution; CHAPS ELECTROPHORESIS REAGENT; MFCD00012116; CHAPS-SOL GRADE; CHAPS; CHAPS extrapure; TREND |
| Molecular Formula | C32H58N2O7S |
| Molecular Weight | 614.88 |
| Purity | 98.00 |
| Density | 1.01 g/mL at 20ºC |
| Melting Point | 156-158ºC |
| Appearance | White crystalline powder |
| Water Solubility | H2O: 50 mg/mL at 20 °C, clear, colorless | Soluble |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | CHAPS is a zwitterionic non-denaturing detergent used to solubilize membrane proteins. |
| HTC | 2934999090 |
| PubChem ID | 329829881 |
| SMILES | CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C |
| InChI | InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1 |
| InChI Key | UMCMPZBLKLEWAF-BCTGSCMUSA-N |
| Hazard Symbols | transportation |
| Bioactivity | CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Target: CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons.CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others References [1]. Ofri D, Ritter AM, Liu YF et al. Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding. J Neurochem. 1992 Feb;58(2):628-35. [2]. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995 Aug 1;77(1):65-78. [3]. Pasquali C, Fialka I, Huber LA. Preparative two-dimensional gel electrophoresis of membrane proteins. Electrophoresis. 1997 Dec;18(14):2573-81. [4]. Menshikova I, Menshikov E, Filenko N, Lyubchenko YL. Nucleosomes structure and dynamics: effect of CHAPS. Int J Biochem Mol Biol. 2011;2(2):129-137. [5]. Krofli? A, Sarac B, Be?ter-Roga? M. Thermodynamic characterization of 3-[(3-cholamidopropyl)-dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence. Langmuir. 2012 Jul 17;28( Chemical & Physical Properties Density 1.01 g/mL at 20ºC Melting Point 156-158ºC Molecular Formula C32H58N2O7S Molecular Weight 614.877 Exact Mass 614.396484 PSA 155.37000 LogP -4.32 Index of Refraction 1.6900 (estimate) InChIKey UMCMPZBLKLEWAF-BCTGSCMUSA-N SMILES CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C Storage condition 2-8°C Stability Moisture Sensitive: Hydroscopic Water Solubility H2O: 50 mg/mL at 20 °C, clear, colorless | Soluble in water (10 mg/ml). Soluble in DMF and hot methanol. |
| Use of | Properties Articles77 Name 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Synonym More Synonyms CHAPS Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others References [1]. Ofri D, Ritter AM, Liu YF et al. Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding. J Neurochem. 1992 Feb;58(2):628-35. [2]. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995 Aug 1;77(1):65-78. [3]. Pasquali C, Fialka I, Huber LA. Preparative two-dimensional gel electrophoresis of membrane proteins. Electrophoresis. 1997 Dec;18(14):2573-81. [5]. Krofli? A, Sarac B, Be?ter-Roga? M. Thermodynamic characterization of 3-[(3-cholamidopropyl)-dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence. Langmuir. 2012 Jul 17;28( Chemical & Physical Properties Molecular Formula C32H58N2O7S Exact Mass 614.396484 PSA 155.37000 LogP -4.32 Index of Refraction 1.6900 (estimate) InChIKey UMCMPZBLKLEWAF-BCTGSCMUSA-N Stability Moisture Sensitive: Hydroscopic |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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