CAS Number75277-39-3
Synonyms1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1); HEPES sodium salt; EINECS 278-169-7; Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate; MFCD00036463; 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
Molecular FormulaC8H17N2NaO4S
Molecular Weight260.29
Purity98.00%
Melting Point234ºC
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 75277-39-3 |
| Catalog No. | 2A-9047852 |
| Chinese Name | N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐 |
| Synonyms | 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1); HEPES sodium salt; EINECS 278-169-7; Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate; MFCD00036463; 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt |
| Molecular Formula | C8H17N2NaO4S |
| Molecular Weight | 260.29 |
| Purity | 98.00 |
| Melting Point | 234ºC |
| Appearance | white powder |
| Water Solubility | H2O: 1 M at 20 °C, clear, colorless |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | HEPES sodium is a non-volatile zwitterionic chemical buffer widely used in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium salt is also an effective inducer of lysosomal biogene |
| HTC | 29335995 |
| PubChem ID | 3139097 |
| SMILES | O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+] |
| InChI | InChI=1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1 |
| InChI Key | RDZTWEVXRGYCFV-UHFFFAOYSA-M |
| Hazard Symbols | transportation |
| Bioactivity | HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro HEPES maintains superhydrophilicity of titanium for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity[1]. HEPES drives lysosome biogenesis, affects MiT/TFE cytoplasmic-nuclear distribution, disrupts global cellular transcriptional profiles, resulting the activation of a MiT/TFE-dependent lysosomal-autophagic gene network in cultured RAW264.7 cells[3]. References [1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. https://pubmed.ncbi.nlm.nih.gov/20631430/ Chemical & Physical Properties Melting Point 234ºC Molecular Formula C8H17N2NaO4S Molecular Weight 260.286 Exact Mass 260.080658 PSA 92.29000 InChIKey RDZTWEVXRGYCFV-UHFFFAOYSA-M SMILES O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+] Storage condition Store at RT. Stability Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents. Water Solubility H2O: 1 M at 20 °C, clear, colorless |
| Use of | HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3]. Properties Articles37 Name sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate Synonym More Synonyms HEPES sodium salt Biological Activity Description HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. Chemical & Physical Properties Molecular Formula C8H17N2NaO4S Exact Mass 260.080658 PSA 92.29000 InChIKey RDZTWEVXRGYCFV-UHFFFAOYSA-M Storage condition Store at RT. Stability Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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