CAS Number74844-91-0
Synonyms(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester; N-BOC-transydro-L-prolinemethylester; 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER; N-BOC-L-Hydroxyproline methyl ester; 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate; BOC-HYDROXYPROLINE-OME; N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester; BOC-L-4-HYDROXYPROLINE METHYL ESTER; N-Boc-trans-hydro-L-prolinemethylester; N-Boc-cis-4-Hydroxy-L-prolinem ethylester; N-Boc-trans-4-Hydroxy-L-prolinemethylester; Boc-Hyp-Ome; (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate; MFCD00076981; BOC-L-HYDROXYPROLINE METHYL ESTER; BOC-L-T-4-HYDROXYPROLINE METHYL ESTER; Boc-trans-4-hydroxy-L-proline methyl est
Molecular FormulaC11H19NO5
Molecular Weight245.27
Purity97%
Density1.2±0.1 g/cm3
Boiling Point335.2±42.0 °C at 760 mmHg
Melting Point92-96 °C (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74844-91-0 |
| Catalog No. | 2A-9047793 |
| Chinese Name | N-BOC-反式-4-羟基-L-脯氨酸甲酯 |
| Synonyms | (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester; N-BOC-transydro-L-prolinemethylester; 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER; N-BOC-L-Hydroxyproline methyl ester; 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate; BOC-HYDROXYPROLINE-OME; N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester; BOC-L-4-HYDROXYPROLINE METHYL ESTER; N-Boc-trans-hydro-L-prolinemethylester; N-Boc-cis-4-Hydroxy-L-prolinem ethylester; N-Boc-trans-4-Hydroxy-L-prolinemethylester; Boc-Hyp-Ome; (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate; MFCD00076981; BOC-L-HYDROXYPROLINE METHYL ESTER; BOC-L-T-4-HYDROXYPROLINE METHYL ESTER; Boc-trans-4-hydroxy-L-proline methyl est |
| Molecular Formula | C11H19NO5 |
| Molecular Weight | 245.27 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 335.2±42.0 °C at 760 mmHg |
| Melting Point | 92-96 °C (lit.) |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Boc-Hyp-OMe is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). Boc Hyp OMe is also a PROTAC linker based on alkyl chains and can be used to synthesize PROTAC[1][2]. |
| HTC | 2933990090 |
| PubChem ID | 24883051 |
| MDL Number | MFCD00076981 |
| SMILES | COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C |
| InChI | 1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8+/m1/s1 |
| InChI Key | MZMNEDXVUJLQAF-SFYZADRCSA-N |
| NACRES Code | NA.22 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| MSDS | msds/47793_1_74844_91_0.pdf |
| Bioactivity | Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 335.2±42.0 °C at 760 mmHg Melting Point 92-96 °C(lit.) Molecular Formula C11H19NO5 Molecular Weight 245.272 Flash Point 156.6±27.9 °C Exact Mass 245.126328 PSA 76.07000 LogP -0.25 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.501 InChIKey MZMNEDXVUJLQAF-SFYZADRCSA-N SMILES COC(=O)C1CC(O)CN1C(=O)OC(C)(C)C Storage condition 2~8°C |
| Use of | Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name N-Boc-trans-4-Hydroxy-L-proline methyl ester Synonym More Synonyms Boc-Hyp-OMe Biological Activity Description Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C11H19NO5 Exact Mass 245.126328 PSA 76.07000 LogP -0.25 Index of Refraction 1.501 InChIKey MZMNEDXVUJLQAF-SFYZADRCSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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