| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72040-63-2 |
| Catalog No. | 2A-9047402 |
| Chinese Name | 生物素化-epsilon-氨基己酸-N-羟基丁二酰亚胺活化酯 |
| Synonyms | MFCD00065502 |
| Molecular Formula | C20H30N4O6S |
| Molecular Weight | 454.54 |
| Purity | ≥98 (TLC) |
| Density | 1.4±0.1 g/cm3 |
| Melting Point | 169-171 °C |
| Appearance | powder |
| Water Solubility | H2O: ≤2 mg/mL with sonication |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Biotin-C5-NHS Ester is a PROTAC linker, belonging to the alkyl/ether class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 24891665 |
| MDL Number | MFCD00065502 |
| SMILES | [H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2 |
| InChI | 1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1 |
| InChI Key | UVGHPGOONBRLCX-NJSLBKSFSA-N |
| Beilstein/REAXYS | 3577403 |
| NACRES Code | NA.46 |
| UNSPSC | 12352203 |
| Hazard Symbols | transportation |
| Bioactivity | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Melting Point 169-171 °C Molecular Formula C20H30N4O6S Molecular Weight 454.540 Exact Mass 454.188599 PSA 159.21000 LogP -1.62 Index of Refraction 1.591 InChIKey UVGHPGOONBRLCX-NJSLBKSFSA-N SMILES O=C(CCCCC1SCC2NC(=O)NC21)NCCCCCC(=O)ON1C(=O)CCC1=O Storage condition −20°C Stability Moisture Sensitive Water Solubility H2O: ≤2 mg/mL with sonication |
| Use of | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Articles15 Name Succinimidyl-6-(biotinamido) Hexanoate Synonym More Synonyms Biotin-C5-NHS Ester Biological Activity Description Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C20H30N4O6S Exact Mass 454.188599 PSA 159.21000 LogP -1.62 Index of Refraction 1.591 InChIKey UVGHPGOONBRLCX-NJSLBKSFSA-N Stability Moisture Sensitive |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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